BPIFB1 promotes metastasis of hormone receptor‐positive breast cancer via inducing macrophage M2 ‐like polarization
Metastasis is an important factor affecting the prognosis of hormone receptor‐positive breast cancer (BC). However, the molecular basis for migration and invasion of tumor cells remains poorly understood. Here, we identify that bactericidal/permeability‐increasing‐fold‐containing family B member 1 (...
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| Published in | Cancer science Vol. 114; no. 11; pp. 4157 - 4171 |
|---|---|
| Main Authors | , , , , , , , , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Tokyo
John Wiley & Sons, Inc
01.11.2023
John Wiley and Sons Inc |
| Subjects | |
| Online Access | Get full text |
| ISSN | 1347-9032 1349-7006 1349-7006 |
| DOI | 10.1111/cas.15957 |
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| Abstract | Metastasis is an important factor affecting the prognosis of hormone receptor‐positive breast cancer (BC). However, the molecular basis for migration and invasion of tumor cells remains poorly understood. Here, we identify that bactericidal/permeability‐increasing‐fold‐containing family B member 1 (BPIFB1), which plays an important role in innate immunity, is significantly elevated in breast cancer and associated with lymph node metastasis. High expression of BPIFB1 and its coding mRNA are significantly associated with poor prognosis of hormone receptor‐positive BC. Using enrichment analysis and constructing immune infiltration evaluation, we predict the potential ability of BPIFB1 to promote macrophage M2 polarization. Finally, we demonstrate that BPIFB1 promotes the metastasis of hormone receptor‐positive BC by stimulating the M2‐like polarization of macrophages via the establishment of BC tumor cells/THP1 co‐culture system, qPCR, Transwell assay, and animal experiments. To our knowledge, this is the first report on the role of BPIFB1 as a tumor promoter by activating the macrophage M2 polarization in hormone receptor‐positive breast carcinoma. Together, these results provide novel insights into the mechanism of BPIFB1 in BC. |
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| AbstractList | Metastasis is an important factor affecting the prognosis of hormone receptor‐positive breast cancer (BC). However, the molecular basis for migration and invasion of tumor cells remains poorly understood. Here, we identify that bactericidal/permeability‐increasing‐fold‐containing family B member 1 (BPIFB1), which plays an important role in innate immunity, is significantly elevated in breast cancer and associated with lymph node metastasis. High expression of BPIFB1 and its coding mRNA are significantly associated with poor prognosis of hormone receptor‐positive BC. Using enrichment analysis and constructing immune infiltration evaluation, we predict the potential ability of BPIFB1 to promote macrophage M2 polarization. Finally, we demonstrate that BPIFB1 promotes the metastasis of hormone receptor‐positive BC by stimulating the M2‐like polarization of macrophages via the establishment of BC tumor cells/THP1 co‐culture system, qPCR, Transwell assay, and animal experiments. To our knowledge, this is the first report on the role of BPIFB1 as a tumor promoter by activating the macrophage M2 polarization in hormone receptor‐positive breast carcinoma. Together, these results provide novel insights into the mechanism of BPIFB1 in BC. BPIFB1 plays a pivotal role in promoting macrophage M2 polarization, which enhances the ability of hormone receptor‐positive breast cancer cells to metastasize. Metastasis is an important factor affecting the prognosis of hormone receptor-positive breast cancer (BC). However, the molecular basis for migration and invasion of tumor cells remains poorly understood. Here, we identify that bactericidal/permeability-increasing-fold-containing family B member 1 (BPIFB1), which plays an important role in innate immunity, is significantly elevated in breast cancer and associated with lymph node metastasis. High expression of BPIFB1 and its coding mRNA are significantly associated with poor prognosis of hormone receptor-positive BC. Using enrichment analysis and constructing immune infiltration evaluation, we predict the potential ability of BPIFB1 to promote macrophage M2 polarization. Finally, we demonstrate that BPIFB1 promotes the metastasis of hormone receptor-positive BC by stimulating the M2-like polarization of macrophages via the establishment of BC tumor cells/THP1 co-culture system, qPCR, Transwell assay, and animal experiments. To our knowledge, this is the first report on the role of BPIFB1 as a tumor promoter by activating the macrophage M2 polarization in hormone receptor-positive breast carcinoma. Together, these results provide novel insights into the mechanism of BPIFB1 in BC.Metastasis is an important factor affecting the prognosis of hormone receptor-positive breast cancer (BC). However, the molecular basis for migration and invasion of tumor cells remains poorly understood. Here, we identify that bactericidal/permeability-increasing-fold-containing family B member 1 (BPIFB1), which plays an important role in innate immunity, is significantly elevated in breast cancer and associated with lymph node metastasis. High expression of BPIFB1 and its coding mRNA are significantly associated with poor prognosis of hormone receptor-positive BC. Using enrichment analysis and constructing immune infiltration evaluation, we predict the potential ability of BPIFB1 to promote macrophage M2 polarization. Finally, we demonstrate that BPIFB1 promotes the metastasis of hormone receptor-positive BC by stimulating the M2-like polarization of macrophages via the establishment of BC tumor cells/THP1 co-culture system, qPCR, Transwell assay, and animal experiments. To our knowledge, this is the first report on the role of BPIFB1 as a tumor promoter by activating the macrophage M2 polarization in hormone receptor-positive breast carcinoma. Together, these results provide novel insights into the mechanism of BPIFB1 in BC. Metastasis is an important factor affecting the prognosis of hormone receptor‐positive breast cancer (BC). However, the molecular basis for migration and invasion of tumor cells remains poorly understood. Here, we identify that bactericidal/permeability‐increasing‐fold‐containing family B member 1 (BPIFB1), which plays an important role in innate immunity, is significantly elevated in breast cancer and associated with lymph node metastasis. High expression of BPIFB1 and its coding mRNA are significantly associated with poor prognosis of hormone receptor‐positive BC. Using enrichment analysis and constructing immune infiltration evaluation, we predict the potential ability of BPIFB1 to promote macrophage M2 polarization. Finally, we demonstrate that BPIFB1 promotes the metastasis of hormone receptor‐positive BC by stimulating the M2‐like polarization of macrophages via the establishment of BC tumor cells/THP1 co‐culture system, qPCR, Transwell assay, and animal experiments. To our knowledge, this is the first report on the role of BPIFB1 as a tumor promoter by activating the macrophage M2 polarization in hormone receptor‐positive breast carcinoma. Together, these results provide novel insights into the mechanism of BPIFB1 in BC. |
| Author | Zou, Yiyun Wang, Ting Ma, Fei Shang, Yuhang Li, Mingcui Yu, Tianshui Chen, Ziang Cheng, Weilun Feng, Jianyuan Duan, Yunqiang Zhang, Hanyu Shakila, Suborna S. Zhang, Jiarui Li, Yanling Hu, Anbang Liu, Yansong Guo, Baoliang Rong, Zhiyuan Ding, Yu |
| AuthorAffiliation | 1 Department of General Surgery The Second Affiliated Hospital of Harbin Medical University Harbin China 2 Department of General Surgery Daqing Oilfield General Hospital Daqing China |
| AuthorAffiliation_xml | – name: 1 Department of General Surgery The Second Affiliated Hospital of Harbin Medical University Harbin China – name: 2 Department of General Surgery Daqing Oilfield General Hospital Daqing China |
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| Copyright | 2023. This work is published under http://creativecommons.org/licenses/by-nc-nd/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. 2023 The Authors. Cancer Science published by John Wiley & Sons Australia, Ltd on behalf of Japanese Cancer Association. 2023 The Authors. published by John Wiley & Sons Australia, Ltd on behalf of Japanese Cancer Association. |
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| Snippet | Metastasis is an important factor affecting the prognosis of hormone receptor‐positive breast cancer (BC). However, the molecular basis for migration and... Metastasis is an important factor affecting the prognosis of hormone receptor-positive breast cancer (BC). However, the molecular basis for migration and... |
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| SubjectTerms | Algorithms Breast cancer Breast carcinoma Cell culture Cloning Estrogens Genes Genomes Innate immunity Leukocyte migration Lung cancer Lymph nodes Lymphatic system Macrophages Medical prognosis Metastases Metastasis mRNA Original ORIGINAL ARTICLES Permeability Polarization Prognosis Proteins Software Tumor cells Tumors |
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| Title | BPIFB1 promotes metastasis of hormone receptor‐positive breast cancer via inducing macrophage M2 ‐like polarization |
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