BPIFB1 promotes metastasis of hormone receptor‐positive breast cancer via inducing macrophage M2 ‐like polarization

• Published in: Cancer science Vol. 114; no. 11; pp. 4157 - 4171
• Main Authors: Hu, Anbang, Liu, Yansong, Zhang, Hanyu, Wang, Ting, Zhang, Jiarui, Cheng, Weilun, Yu, Tianshui, Duan, Yunqiang, Feng, Jianyuan, Chen, Ziang, Ding, Yu, Li, Yanling, Li, Mingcui, Rong, Zhiyuan, Shang, Yuhang, Shakila, Suborna S., Zou, Yiyun, Ma, Fei, Guo, Baoliang
• Format: Journal Article
• Language: English
• Published: Tokyo John Wiley & Sons, Inc 01.11.2023; John Wiley and Sons Inc
• Subjects: Algorithms; Breast cancer; Breast carcinoma; Cell culture; Cloning; Estrogens; Genes; Genomes; Innate immunity; Leukocyte migration; Lung cancer; Lymph nodes; Lymphatic system; Macrophages; Medical prognosis; Metastases; Metastasis; mRNA; Original; ORIGINAL ARTICLES; Permeability; Polarization; Prognosis; Proteins; Software; Tumor cells; Tumors; China
• ISSN: 1347-9032; 1349-7006; 1349-7006
• DOI: 10.1111/cas.15957

Metastasis is an important factor affecting the prognosis of hormone receptor‐positive breast cancer (BC). However, the molecular basis for migration and invasion of tumor cells remains poorly understood. Here, we identify that bactericidal/permeability‐increasing‐fold‐containing family B member 1 (BPIFB1), which plays an important role in innate immunity, is significantly elevated in breast cancer and associated with lymph node metastasis. High expression of BPIFB1 and its coding mRNA are significantly associated with poor prognosis of hormone receptor‐positive BC. Using enrichment analysis and constructing immune infiltration evaluation, we predict the potential ability of BPIFB1 to promote macrophage M2 polarization. Finally, we demonstrate that BPIFB1 promotes the metastasis of hormone receptor‐positive BC by stimulating the M2‐like polarization of macrophages via the establishment of BC tumor cells/THP1 co‐culture system, qPCR, Transwell assay, and animal experiments. To our knowledge, this is the first report on the role of BPIFB1 as a tumor promoter by activating the macrophage M2 polarization in hormone receptor‐positive breast carcinoma. Together, these results provide novel insights into the mechanism of BPIFB1 in BC.