A Case of Mixed Adenoneuroendocrine Carcinoma of the Common Bile Duct: Initially Diagnosed as Cholangiocarcinoma

• Published in: Journal of pathology and translational medicine Vol. 48; no. 6; pp. 445 - 448
• Main Authors: Lee, Soon Wook, Lee, In Seok, Cho, Yu Kyung, Park, Jae Myung, Kim, Sang Woo, Choi, Myung-Gyu, Choi, Kyu Yong, Lee, Myung Ah, Hong, Tae Ho, You, Young Kyoung, Jung, Eun-Sun
• Format: Journal Article
• Language: English
• Published: Korea (South) Korean Society of Pathologists, Korean Society for Cytopathology 01.12.2014; The Korean Society of Pathologists and The Korean Society for Cytopathology; 대한병리학회
• Subjects: Bile; Biopsy; Brief Case Report; Cancer; Cancer therapies; Histology; Medical prognosis; Tomography; Tumors; 병리학
• ISSN: 1738-1843; 2383-7837; 2092-8920; 2383-7845
• DOI: 10.4132/KoreanJPathol.2014.48.6.445

[...]due to the limitation involved with obtaining adequate biopsy specimens, ERCP may fail to reach the neuroendocrine component, which is embedded in a deeper portion of the tumor. [...]the pathologic diagnosis of MANEC using a surgically resected specimen with immunohistochemical stainining for neuroendocrine markers (chromogranin, synaptophysin, and CD56) may be useful for the correct diagnosis.3 Even in surgical specimens of biliary tract cancer, NETs and MANECs may be hidden inside the adenocarcinomatous components. Most MANEC cases, including this one, are initially diagnosed as cholangiocarcinoma. [...]the acquisition of a surgical specimen and thorough investigations by the pathologist are crucial to make the correct diagnosis in order to determine the best treatment and estimate the prognosis in extra-hepatic bile duct cancer.