Short-term and long-term outcomes of liver transplantation using moderately and severely steatotic donor livers: A systematic review

• Published in: Medicine (Baltimore) Vol. 97; no. 35; p. e12026
• Main Authors: Wu, Chenjiao, Lu, Chao, Xu, Chengfu
• Format: Journal Article
• Language: English
• Published: United States The Authors. Published by Wolters Kluwer Health, Inc. All rights reserved 01.08.2018; Wolters Kluwer Health
• Subjects: Fatty Liver - physiopathology; Graft Survival; Humans; Liver Transplantation - adverse effects; Liver Transplantation - methods; Liver Transplantation - mortality; Postoperative Complications; Severity of Illness Index; Systematic Review and Meta-Analysis; Tissue Donors - statistics & numerical data
• ISSN: 0025-7974; 1536-5964; 1536-5964
• DOI: 10.1097/MD.0000000000012026

The aim of this study was to perform a systemic review of the studies addressing the use of moderately and severely steatotic donor livers for liver transplantation. We searched the following electronic databases from January 1, 1989, to August 1, 2017: PubMed, EMBASE, Science Citation Index Expanded, and the Cochrane Library. In addition, reference lists were scanned to identify any additional reports. The quality of published papers was assessed. The main outcomes of the use of moderately and severely steatotic donor livers for liver transplantation, including primary nonfunction, short-term mortality, and long-term mortality, were extracted for pooled analysis. Literature searches identified 16 studies that met the inclusion criteria. There were no randomized controlled studies, and all of the studies were retrospective or prospective case series. From a total of 3226 subjects (532 moderately and severely steatotic donor livers and 2694 controls), we found a significant increase in primary nonfunction [odds ratio (OR): 2.47, 95% confidence interval (95% CI): 1.44-4.27], and a trend of increase in 1-month patient mortality (OR: 1.90, 95% CI: 0.98-3.71) with the use of moderately and severely steatotic donor livers, whereas the 1-year mortality was relatively less influenced. The use of moderately and severely steatotic livers is associated with unfavorable short-term outcomes, but long-term outcomes are relatively less influenced.