HELLP Syndrome Is Associated with an Increased Inflammatory Response, Which May Be Inhibited by Administration of Prednisolone

• Published in: Hypertension in pregnancy Vol. 27; no. 3; pp. 253 - 265
• Main Authors: van Runnard Heimel, Pieter J., Kavelaars, Annemiek, Heijnen, Cobie J., Peters, Wilbert H. M., Huisjes, Anjoke J. M., Franx, Arie, Bruinse, Hein W.
• Format: Journal Article
• Language: English
• Published: England Informa UK Ltd 01.01.2008; Taylor & Francis
• Subjects: Adult; Anti-Inflammatory Agents - therapeutic use; Biomarkers - blood; Case-Control Studies; Corticosteroids; Female; HELLP syndrome; HELLP Syndrome - blood; HELLP Syndrome - drug therapy; Humans; Inflammation - blood; Inflammation - drug therapy; Inflammatory response; Prednisolone - therapeutic use; Preeclampsia; Pregnancy
• ISSN: 1064-1955; 1525-6065; 1525-6065
• DOI: 10.1080/10641950802174953

Objective. To investigate the effect of prednisolone on HELLP syndrome by assessing several markers of the inflammatory response and hepatic damage associated with HELLP syndrome. Design. Prospective study. Setting. Single-center, tertiary obstetric care facility at the University Medical Centre Utrecht, The Netherlands. Population. Study subjects included normal controls, patients with non-HELLP preeclampsia, and patients with preeclampsia and HELLP syndrome. Methods. HELLP syndrome was defined by hemolysis (serum lactate dehydrogenase [LDH] >600 IU L and or haptoglobin ≤0.3 g L), elevated liver enzymes (serum aspartate aminotransferase [AST] >70 U L and or serum alanine aminotransferase [ALT] >70 U L), and a low platelet count (<100 × 109 L). Blood samples from patients with HELLP syndrome who were receiving either prednisolone or placebo were obtained before, during, and after a HELLP exacerbation in the antepartum period. Plasma levels of CRP, IL-1RA, IL-6, sIL-6R, IL-8, IL-10, TNF-α, and GSTA1-1 were determined. Samples from women with preeclampsia but without HELLP syndrome and from healthy pregnant women were included as controls. Main Outcome Measures. Plasma levels of CRP, IL-1RA, IL-6, sIL-6R, IL-8, IL-10, TNF-α, and GSTA1-1. Results. During a HELLP exacerbation CRP, IL-6, IL-1Ra, and GSTA1-1 levels are significantly increased (p < 0.01). In the group of patients treated with prednisolone, significantly lower IL-6 levels were observed during a HELLP exacerbation, compared with patients who did not receive prednisolone (p < 0.01). Conclusion.HELLP syndrome is associated with an increased inflammatory response. Circulating IL-6 levels in HELLP syndrome are reduced during prednisolone administration, suggesting a stabilizing effect on the inflammatory endothelial process.