Fundamental Neurochemistry Review: Microglial immunometabolism in traumatic brain injury

• Published in: Journal of neurochemistry Vol. 167; no. 2; pp. 129 - 153
• Main Authors: Strogulski, Nathan R., Portela, Luis V., Polster, Brian M., Loane, David J.
• Format: Journal Article
• Language: English
• Published: England Blackwell Publishing Ltd 01.10.2023
• Subjects: Animals; Anti-Inflammatory Agents; Brain; Brain damage; Brain Injuries, Traumatic - metabolism; Environmental effects; Glycolysis; Head injuries; Immune response; Immune system; Immunosurveillance; Impact damage; Inflammation; Lipid peroxidation; Lipids; Macrophages; Metabolic disorders; Metabolic pathways; Metabolism; Metabolites; Mice; Mice, Inbred C57BL; Microglia; Microglia - metabolism; Mitochondria; Neurochemistry; Neurodegeneration; Neuroinflammatory Diseases; Neurological diseases; Oxidation; Oxidative metabolism; Pain perception; Pentose; Pentose phosphate pathway; Phagocytosis; Phenotypes; Phenotyping; Reactive oxygen species; Stimuli; Traumatic brain injury; traumatic brain injury; neuroimmunology; metabolism; microglia; mitochondria
• ISSN: 0022-3042; 1471-4159; 1471-4159
• DOI: 10.1111/jnc.15959

Traumatic brain injury (TBI) is a devastating neurological disorder caused by a physical impact to the brain that promotes diffuse damage and chronic neurodegeneration. Key mechanisms believed to support secondary brain injury include mitochondrial dysfunction and chronic neuroinflammation. Microglia and brain‐infiltrating macrophages are responsible for neuroinflammatory cytokine and reactive oxygen species (ROS) production after TBI. Their production is associated with loss of homeostatic microglial functions such as immunosurveillance, phagocytosis, and immune resolution. Beyond providing energy support, mitochondrial metabolic pathways reprogram the pro‐ and anti‐inflammatory machinery in immune cells, providing a critical immunometabolic axis capable of regulating immunologic response to noxious stimuli. In the brain, the capacity to adapt to different environmental stimuli derives, in part, from microglia's ability to recognize and respond to changes in extracellular and intracellular metabolite levels. This capacity is met by an equally plastic metabolism, capable of altering immune function. Microglial pro‐inflammatory activation is associated with decreased mitochondrial respiration, whereas anti‐inflammatory microglial polarization is supported by increased oxidative metabolism. These metabolic adaptations contribute to neuroimmune responses, placing mitochondria as a central regulator of post‐traumatic neuroinflammation. Although it is established that profound neurometabolic changes occur following TBI, key questions related to metabolic shifts in microglia remain unresolved. These include (a) the nature of microglial mitochondrial dysfunction after TBI, (b) the hierarchical positions of different metabolic pathways such as glycolysis, pentose phosphate pathway, glutaminolysis, and lipid oxidation during secondary injury and recovery, and (c) how immunometabolism alters microglial phenotypes, culminating in chronic non‐resolving neuroinflammation. In this basic neurochemistry review article, we describe the contributions of immunometabolism to TBI, detail primary evidence of mitochondrial dysfunction and metabolic impairments in microglia and macrophages, discuss how major metabolic pathways contribute to post‐traumatic neuroinflammation, and set out future directions toward advancing immunometabolic phenotyping in TBI. image