Transforming Olefins into Dinucleophiles

Herein we present the first example of a three-component dicarbofunctionalization of olefins under reductive conditions. Our strategy takes advantage of nickel catalysis to add aryl and alkyl groups across the double bond with remarkable selectivity. The reaction shows broad functional group compati...

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Bibliographic Details
Published inChimia Vol. 72; no. 4; p. 212
Main Authors García-Domínguez, Andrés, Nevado, Cristina
Format Journal Article
LanguageEnglish
Published Switzerland Swiss Chemical Society 25.04.2018
Subjects
Cross-coupling
Dicarbofunctionalization
Nickel catalysis
Tdae
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ISSN0009-4293
2673-2424
DOI10.2533/chimia.2018.212

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Summary:Herein we present the first example of a three-component dicarbofunctionalization of olefins under reductive conditions. Our strategy takes advantage of nickel catalysis to add aryl and alkyl groups across the double bond with remarkable selectivity. The reaction shows broad functional group compatibility and more importantly, it proves to be general in terms of the alkenes that can be functionalized compared to previous dicarbofunctionalization methods. Initial control experiments reveal different activation modes for both electrophiles and the involvement of alkyl radicals throughout the reaction.
ISSN:0009-4293
2673-2424
DOI:10.2533/chimia.2018.212