Adenovirus vectors activate Vδ2+ γδT cells in a type I interferon‐, TNF‐, and IL‐18‐dependent manner
Vδ2+ γδT cells are unconventional T cells that can be activated by cytokines without TCR signaling. Adenovirus vaccine vectors activated Vδ2+ γδT cells in an interleukin 18‐, TNF‐, and type I interferon‐dependent manner. This stimulatory capacity was associated with adenovirus vectors of non‐species...
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Published in | European journal of immunology Vol. 52; no. 5; pp. 835 - 837 |
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Main Authors | , , , , , , , , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
Germany
Wiley Subscription Services, Inc
01.05.2022
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Subjects | |
Online Access | Get full text |
ISSN | 0014-2980 1521-4141 1521-4141 |
DOI | 10.1002/eji.202149367 |
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Summary: | Vδ2+ γδT cells are unconventional T cells that can be activated by cytokines without TCR signaling. Adenovirus vaccine vectors activated Vδ2+ γδT cells in an interleukin 18‐, TNF‐, and type I interferon‐dependent manner. This stimulatory capacity was associated with adenovirus vectors of non‐species C origin, including the ChAdOx1 vaccine platform. |
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Bibliography: | Authors Nicholas M. Provine and Ali Amini contributed equally to this work. Present address: Christine S. Rollier, School of Biosciences and Medicine, University of Surrey, Guildford, UK. ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 |
ISSN: | 0014-2980 1521-4141 1521-4141 |
DOI: | 10.1002/eji.202149367 |