Adenovirus vectors activate Vδ2+ γδT cells in a type I interferon‐, TNF‐, and IL‐18‐dependent manner

Vδ2+ γδT cells are unconventional T cells that can be activated by cytokines without TCR signaling. Adenovirus vaccine vectors activated Vδ2+ γδT cells in an interleukin 18‐, TNF‐, and type I interferon‐dependent manner. This stimulatory capacity was associated with adenovirus vectors of non‐species...

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Published inEuropean journal of immunology Vol. 52; no. 5; pp. 835 - 837
Main Authors Provine, Nicholas M., Amini, Ali, Garner, Lucy C., FitzPatrick, Michael E.B., Dold, Christina, Silva Reyes, Laura, Chinnakannan, Senthil, Oguti, Blanche, Raymond, Meriel, Troise, Fulvia, Capone, Stefania, Folgori, Antonella, Barnes, Eleanor, Rollier, Christine S., Pollard, Andrew J., Klenerman, Paul
Format Journal Article
LanguageEnglish
Published Germany Wiley Subscription Services, Inc 01.05.2022
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ISSN0014-2980
1521-4141
1521-4141
DOI10.1002/eji.202149367

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Summary:Vδ2+ γδT cells are unconventional T cells that can be activated by cytokines without TCR signaling. Adenovirus vaccine vectors activated Vδ2+ γδT cells in an interleukin 18‐, TNF‐, and type I interferon‐dependent manner. This stimulatory capacity was associated with adenovirus vectors of non‐species C origin, including the ChAdOx1 vaccine platform.
Bibliography:Authors Nicholas M. Provine and Ali Amini contributed equally to this work.
Present address: Christine S. Rollier, School of Biosciences and Medicine, University of Surrey, Guildford, UK.
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ISSN:0014-2980
1521-4141
1521-4141
DOI:10.1002/eji.202149367