Diagnosis of Good Syndrome following Recurrent Coronavirus Disease-2019 Infections

Background: Good syndrome is defined as the co-occurrence of a thymoma and hypogammaglobulinemia. Case: In this case report, we present a patient who was diagnosed with Good syndrome following recurrent infections with SARS-CoV-2. Of particular note was the patient’s repeated presentation despite re...

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Bibliographic Details
Published inCase reports in oncology Vol. 18; no. 1; pp. 107 - 112
Main Authors Beiser, Moshe, Sabari, Joshua K.
Format Journal Article
LanguageEnglish
Published Switzerland S. Karger AG 01.01.2025
Karger Publishers
Subjects
Case Report
COVID-19
Intravenous immunoglobulin
Hypogammaglobulinemia
Thymoma
Good syndrome
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ISSN1662-6575
1662-6575
DOI10.1159/000542928

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Summary:Background: Good syndrome is defined as the co-occurrence of a thymoma and hypogammaglobulinemia. Case: In this case report, we present a patient who was diagnosed with Good syndrome following recurrent infections with SARS-CoV-2. Of particular note was the patient’s repeated presentation despite receiving outpatient treatment with nirmatrelvir-ritonavir. We describe the patient’s presentation, diagnosis, and treatment – including robotic thymectomy and passive immunization with IVIG – and report the benefit to quality of life that the patient experienced. Conclusion: This case highlights the importance of quantitative testing of immunoglobulins in patients with known thymomas who present with recurrent infections of SARS-CoV-2.
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ISSN:1662-6575
1662-6575
DOI:10.1159/000542928