Variation of Serum Monocyte Chemoattractant Protein-1 in Patients with Diabetes and Metabolic Syndrome

• Published in: Journal of Huazhong University of Science and Technology. Medical sciences Vol. 31; no. 3; pp. 312 - 316
• Main Author: 黎慧清 邓秀玲 李贞琼 罗长青 刘建社 王玉梅
• Format: Journal Article
• Language: English
• Published: Heidelberg Huazhong University of Science and Technology 01.06.2011
• Subjects: Adult; Age; Blood pressure; Body mass index; Chemokine CCL2 - blood; Diabetes mellitus; Diabetes Mellitus, Type 2 - blood; Diabetes Mellitus, Type 2 - complications; Fasting; Female; Glucose; Hip; Humans; Inflammation; Inflammation - etiology; Insulin; Insulin Resistance; Male; MCP; Medicine; Medicine & Public Health; Metabolic disorders; Metabolic Syndrome - blood; Metabolic Syndrome - complications; Middle Aged; Monocyte chemoattractant protein 1; Obesity; Obesity, Abdominal - complications; Serum levels; Triglycerides; 代谢综合征; 单核细胞趋化蛋白-1; 患者; 空腹血糖; 糖尿病; 胰岛素抵抗; 血清甘油三酯; metabolic syndrome; monocyte chemoattractant protein-1; diabetes
• ISSN: 1672-0733; 1993-1352
• DOI: 10.1007/s11596-011-0373-8

This study investigated the variation of serum monocyte chemoattractant protein-1（MCP-1） in patients with both diabetes mellitus（DM） and metabolic syndrome（MS）.Based on the International Diabetes Federation（IDF） diagnostic criteria,93 patients enrolled in this study were divided into four groups：normal control（NC）,simple DM,simple MS,and DM plus MS（DM-MS） groups.The main measures included height,weight,waist circumference（WC）,hip circumference,blood pressure,fasting blood glucose,insulin resistance index（HOMA-IR）,serum triglyceride（TG）,HDL-ch,LDL-ch,and MCP-1.The results showed that the serum levels of MCP-1 in the DM-MS group were significantly increased as compared with those in the DM and MS groups（P0.05）,and the increase in the MCP-1 level in the DM group was much higher than in the MS group（P0.05）.The DM-MS group had the highest HOMA-IR levels,followed by MS,DM and NC groups（P0.05）.Correlation tests showed that the association of MCP-1 with age,HDL-ch,or LDL-ch was insignificant,whereas that of MCP-1 with body mass index（BMI）,waist hip rate（WHR）,WC,systolic blood pressure（SBP）,diastolic blood pressure（DBP）,TG,and HOMA-IR was significantly positive.It was concluded that circulating MCP-1 was substantially increased in patients with both DM and MS as compared with that in the patients with DM or MS alone,and the central obese state may contribute to a more vicious proinflammatory condition and insulin resistance in patients with diabetes.