Short-term morbidity following primary closure, skin grafting and flap reconstruction after surgical resection of extremity soft-tissue sarcomas: Pushing the limits of limb preservation

• Published in: European journal of surgical oncology Vol. 51; no. 6; p. 109705
• Main Authors: Generaal, J.D., Bosscher, M.R.F., Been, L.B., van Leeuwen, B.L.
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.06.2025
• Subjects: Adult; Aged; Complications; Extremities - surgery; Female; Flap; Humans; Length of Stay - statistics & numerical data; Limb Salvage - methods; Male; Middle Aged; Morbidity; Netherlands - epidemiology; Patient Readmission - statistics & numerical data; Plastic Surgery Procedures - methods; Postoperative Complications - epidemiology; Reconstructive surgery; Retrospective Studies; Sarcoma - surgery; Skin Transplantation; Soft Tissue Neoplasms - surgery; Soft-tissue sarcoma; Surgery; Surgical Flaps; Netherlands; Flap; Complications; Surgery; Reconstructive surgery; Morbidity; Soft-tissue sarcoma
• ISSN: 0748-7983; 1532-2157; 1532-2157
• DOI: 10.1016/j.ejso.2025.109705

Understanding short-term morbidity following extremity soft-tissue sarcoma (ESTS) treatment remains complex due to diverse findings and the absence of a standardized wound complication assessment. This retrospective cohort study evaluated short-term morbidity following primary closure, skin grafting, and flap reconstruction. All ESTS patients treated in a sarcoma center in the Netherlands from 1-1–2010 until 1-8-2022 were included. Short-term morbidity, defined as a wound complication following surgery, was assessed by the Toronto Sarcoma Flap Score (TSFS). The TSFS is an ordinal scale, where 0 indicates the absence of complications, while 10 signifies reconstructive failure necessitating amputation. Hospital stay duration and readmission rates were also analyzed. Limb preservation was achieved in 128 (97.7 %) of 131 patients. Wound complications occurred in 43 (44.3 %) of patients with primary closure, 8 (57.1 %) with skin grafting and 16 (80.0 %) with flap reconstruction, p = 0.01. Patients undergoing flap reconstructions had higher TSFSs (6 [IQR 7], versus 0 [IQR 3] for primary closure and 3 [IQR 6] for skin grafting), longer duration of hospital stays (14 [IQR 18] days versus 4 [IQR 3] days for primary closure and 5 [IQR 7] days for skin grafting, p < 0.01) and were more frequently readmitted (40.0 %, versus 17.5 % for primary closure and 21.4 % for skin grafting, p = 0.09). High limb preservation rates were achieved. Reconstructive surgery allows for the closure of extensive soft-tissue defects following ESTS resection, but it adds to surgical complexity. Patients undergoing flap reconstruction seem to be at a higher risk of short-term morbidity.