The Possible Roles of OPN-Regulated CEACAM1 Expression in Promoting the Survival of Activated T Cells and the Apoptosis of Oral Keratinocytes in Oral Lichen Planus Patients

• Published in: Journal of clinical immunology Vol. 31; no. 5; pp. 827 - 839
• Main Authors: Liu, Gui-Xiang, Xie, Qi, Zhou, Cheng-Jun, Zhang, Xiao-Ying, Ma, Bo-Long, Wang, Cheng-Qin, Wei, Feng-Cai, Qu, Xun, Sun, Shan-Zhen
• Format: Journal Article
• Language: English
• Published: Boston Springer US 01.10.2011; Springer Nature B.V
• Subjects: Adult; Antibodies, Blocking - pharmacology; Antigens, CD - genetics; Antigens, CD - immunology; Antigens, CD - metabolism; Apoptosis - drug effects; Autoimmunity; Biomedical and Life Sciences; Biomedicine; Cell Adhesion Molecules - genetics; Cell Adhesion Molecules - immunology; Cell Adhesion Molecules - metabolism; Cell Proliferation - drug effects; Cells, Cultured; Female; Gene Expression Regulation - drug effects; Humans; Immunohistochemistry; Immunology; Infectious Diseases; Internal Medicine; Keratinocytes - drug effects; Keratinocytes - immunology; Keratinocytes - metabolism; Keratinocytes - pathology; Lichen Planus, Oral - immunology; Lichen Planus, Oral - pathology; Lichen Planus, Oral - physiopathology; Lymphocyte Activation - drug effects; Male; Medical Microbiology; Middle Aged; Mouth Mucosa - pathology; Osteopontin - immunology; Osteopontin - pharmacology; Stomatitis; T-Lymphocytes - drug effects; T-Lymphocytes - immunology; T-Lymphocytes - metabolism; T-Lymphocytes - pathology; osteopontin (OPN); Oral lichen planus (OLP); apoptosis; autoimmune; carcinoembryonic antigen-related cellular adhesion molecule 1 (CEACAM1)
• ISSN: 0271-9142; 1573-2592; 1573-2592
• DOI: 10.1007/s10875-011-9552-4

Oral lichen planus is a chronic inflammatory disorder of the oral mucosa that represents T cell-mediated autoimmune diseases. The regulation and roles of carcinoembryonic antigen-related cellular adhesion molecule 1 (CEACAM1), a novel immune molecule, in the immunopathogenesis of T cell-mediated autoimmune diseases remain unclear. In the current paper, CEACAM1 was found to be overexpressed in peripheral T cells and epithelial cells in oral lichen planus patients. A fraction of infiltrating inflammatory mononuclear cells in the lamina propria of the oral lichen planus mucosa also expressed CEACAM1. Importantly, for the first time, CEACAM1 expression in T cells and in normal human oral keratinocytes was demonstrated to be regulated differently by osteopontin in vitro. Furthermore, the apoptosis of oral keratinocytes and activated T cells can be markedly suppressed by CEACAM1-specific monoclonal antibodies. In conclusion, OPN-regulated CEACAM1 expression may play a critical role in the immunopathogenesis of oral lichen planus.