Trophoblastic disease and choriocarcinoma
Gestational trophoblastic disease (GTD) is a group of diseases associated with pregnancies that demonstrate abnormal development of trophoblastic cells. GTD includes hydatidiform moles (HM) that may continue to further develop into gestational trophoblastic neoplasms (GTN), such as choriocarcinoma (...
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Published in | European journal of surgical oncology Vol. 51; no. 4; p. 108727 |
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Main Authors | , , |
Format | Journal Article |
Language | English |
Published |
England
Elsevier Ltd
01.04.2025
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Online Access | Get full text |
ISSN | 0748-7983 1532-2157 1532-2157 |
DOI | 10.1016/j.ejso.2024.108727 |
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Abstract | Gestational trophoblastic disease (GTD) is a group of diseases associated with pregnancies that demonstrate abnormal development of trophoblastic cells. GTD includes hydatidiform moles (HM) that may continue to further develop into gestational trophoblastic neoplasms (GTN), such as choriocarcinoma (CC). Gestational CC is a malignant mass development that may arise from HM, from other (normal) pregnancies or from other gestational events (such as ectopic pregnancies). The aim of this review is to outline current understating of the genetics and epigenetics of GTD and gestational CC and the link between the two diseases. |
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AbstractList | Gestational trophoblastic disease (GTD) is a group of diseases associated with pregnancies that demonstrate abnormal development of trophoblastic cells. GTD includes hydatidiform moles (HM) that may continue to further develop into gestational trophoblastic neoplasms (GTN), such as choriocarcinoma (CC). Gestational CC is a malignant mass development that may arise from HM, from other (normal) pregnancies or from other gestational events (such as ectopic pregnancies). The aim of this review is to outline current understating of the genetics and epigenetics of GTD and gestational CC and the link between the two diseases. Gestational trophoblastic disease (GTD) is a group of diseases associated with pregnancies that demonstrate abnormal development of trophoblastic cells. GTD includes hydatidiform moles (HM) that may continue to further develop into gestational trophoblastic neoplasms (GTN), such as choriocarcinoma (CC). Gestational CC is a malignant mass development that may arise from HM, from other (normal) pregnancies or from other gestational events (such as ectopic pregnancies). The aim of this review is to outline current understating of the genetics and epigenetics of GTD and gestational CC and the link between the two diseases.Gestational trophoblastic disease (GTD) is a group of diseases associated with pregnancies that demonstrate abnormal development of trophoblastic cells. GTD includes hydatidiform moles (HM) that may continue to further develop into gestational trophoblastic neoplasms (GTN), such as choriocarcinoma (CC). Gestational CC is a malignant mass development that may arise from HM, from other (normal) pregnancies or from other gestational events (such as ectopic pregnancies). The aim of this review is to outline current understating of the genetics and epigenetics of GTD and gestational CC and the link between the two diseases. |
ArticleNumber | 108727 |
Author | Said, Edith Calleja-Aguis, Jean Camilleri, Graziella |
Author_xml | – sequence: 1 givenname: Graziella orcidid: 0000-0003-3537-1488 surname: Camilleri fullname: Camilleri, Graziella email: graziella.camilleri.09@um.edu.mt organization: Department of Anatomy, Faculty of Medicine and Surgery University of Malta, Malta – sequence: 2 givenname: Jean orcidid: 0000-0001-6369-0297 surname: Calleja-Aguis fullname: Calleja-Aguis, Jean organization: Department of Anatomy, Faculty of Medicine and Surgery University of Malta, Malta – sequence: 3 givenname: Edith surname: Said fullname: Said, Edith organization: Department of Anatomy, Faculty of Medicine and Surgery University of Malta, Malta |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/39370364$$D View this record in MEDLINE/PubMed |
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Keywords | Choriocarcinoma Molar pregnancy Gestational neoplasms Hydatidiform mole Gestational trophoblastic disease |
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Snippet | Gestational trophoblastic disease (GTD) is a group of diseases associated with pregnancies that demonstrate abnormal development of trophoblastic cells. GTD... |
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SubjectTerms | Choriocarcinoma Choriocarcinoma - genetics Choriocarcinoma - pathology Epigenesis, Genetic Female Gestational neoplasms Gestational trophoblastic disease Gestational Trophoblastic Disease - genetics Gestational Trophoblastic Disease - pathology Humans Hydatidiform mole Hydatidiform Mole - genetics Hydatidiform Mole - pathology Molar pregnancy Pregnancy Uterine Neoplasms - genetics Uterine Neoplasms - pathology |
Title | Trophoblastic disease and choriocarcinoma |
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