Trophoblastic disease and choriocarcinoma

Gestational trophoblastic disease (GTD) is a group of diseases associated with pregnancies that demonstrate abnormal development of trophoblastic cells. GTD includes hydatidiform moles (HM) that may continue to further develop into gestational trophoblastic neoplasms (GTN), such as choriocarcinoma (...

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Published inEuropean journal of surgical oncology Vol. 51; no. 4; p. 108727
Main Authors Camilleri, Graziella, Calleja-Aguis, Jean, Said, Edith
Format Journal Article
LanguageEnglish
Published England Elsevier Ltd 01.04.2025
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ISSN0748-7983
1532-2157
1532-2157
DOI10.1016/j.ejso.2024.108727

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Abstract Gestational trophoblastic disease (GTD) is a group of diseases associated with pregnancies that demonstrate abnormal development of trophoblastic cells. GTD includes hydatidiform moles (HM) that may continue to further develop into gestational trophoblastic neoplasms (GTN), such as choriocarcinoma (CC). Gestational CC is a malignant mass development that may arise from HM, from other (normal) pregnancies or from other gestational events (such as ectopic pregnancies). The aim of this review is to outline current understating of the genetics and epigenetics of GTD and gestational CC and the link between the two diseases.
AbstractList Gestational trophoblastic disease (GTD) is a group of diseases associated with pregnancies that demonstrate abnormal development of trophoblastic cells. GTD includes hydatidiform moles (HM) that may continue to further develop into gestational trophoblastic neoplasms (GTN), such as choriocarcinoma (CC). Gestational CC is a malignant mass development that may arise from HM, from other (normal) pregnancies or from other gestational events (such as ectopic pregnancies). The aim of this review is to outline current understating of the genetics and epigenetics of GTD and gestational CC and the link between the two diseases.
Gestational trophoblastic disease (GTD) is a group of diseases associated with pregnancies that demonstrate abnormal development of trophoblastic cells. GTD includes hydatidiform moles (HM) that may continue to further develop into gestational trophoblastic neoplasms (GTN), such as choriocarcinoma (CC). Gestational CC is a malignant mass development that may arise from HM, from other (normal) pregnancies or from other gestational events (such as ectopic pregnancies). The aim of this review is to outline current understating of the genetics and epigenetics of GTD and gestational CC and the link between the two diseases.Gestational trophoblastic disease (GTD) is a group of diseases associated with pregnancies that demonstrate abnormal development of trophoblastic cells. GTD includes hydatidiform moles (HM) that may continue to further develop into gestational trophoblastic neoplasms (GTN), such as choriocarcinoma (CC). Gestational CC is a malignant mass development that may arise from HM, from other (normal) pregnancies or from other gestational events (such as ectopic pregnancies). The aim of this review is to outline current understating of the genetics and epigenetics of GTD and gestational CC and the link between the two diseases.
ArticleNumber 108727
Author Said, Edith
Calleja-Aguis, Jean
Camilleri, Graziella
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Issue 4
Keywords Choriocarcinoma
Molar pregnancy
Gestational neoplasms
Hydatidiform mole
Gestational trophoblastic disease
Language English
License This is an open access article under the CC BY license.
Copyright © 2024 The Authors. Published by Elsevier Ltd.. All rights reserved.
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Snippet Gestational trophoblastic disease (GTD) is a group of diseases associated with pregnancies that demonstrate abnormal development of trophoblastic cells. GTD...
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SubjectTerms Choriocarcinoma
Choriocarcinoma - genetics
Choriocarcinoma - pathology
Epigenesis, Genetic
Female
Gestational neoplasms
Gestational trophoblastic disease
Gestational Trophoblastic Disease - genetics
Gestational Trophoblastic Disease - pathology
Humans
Hydatidiform mole
Hydatidiform Mole - genetics
Hydatidiform Mole - pathology
Molar pregnancy
Pregnancy
Uterine Neoplasms - genetics
Uterine Neoplasms - pathology
Title Trophoblastic disease and choriocarcinoma
URI https://www.clinicalkey.com/#!/content/1-s2.0-S0748798324007844
https://dx.doi.org/10.1016/j.ejso.2024.108727
https://www.ncbi.nlm.nih.gov/pubmed/39370364
https://www.proquest.com/docview/3113746595
Volume 51
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