Trophoblastic disease and choriocarcinoma

• Published in: European journal of surgical oncology Vol. 51; no. 4; p. 108727
• Main Authors: Camilleri, Graziella, Calleja-Aguis, Jean, Said, Edith
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.04.2025
• Subjects: Choriocarcinoma; Choriocarcinoma - genetics; Choriocarcinoma - pathology; Epigenesis, Genetic; Female; Gestational neoplasms; Gestational trophoblastic disease; Gestational Trophoblastic Disease - genetics; Gestational Trophoblastic Disease - pathology; Humans; Hydatidiform mole; Hydatidiform Mole - genetics; Hydatidiform Mole - pathology; Molar pregnancy; Pregnancy; Uterine Neoplasms - genetics; Uterine Neoplasms - pathology; Choriocarcinoma; Molar pregnancy; Gestational neoplasms; Hydatidiform mole; Gestational trophoblastic disease
• ISSN: 0748-7983; 1532-2157; 1532-2157
• DOI: 10.1016/j.ejso.2024.108727

Gestational trophoblastic disease (GTD) is a group of diseases associated with pregnancies that demonstrate abnormal development of trophoblastic cells. GTD includes hydatidiform moles (HM) that may continue to further develop into gestational trophoblastic neoplasms (GTN), such as choriocarcinoma (CC). Gestational CC is a malignant mass development that may arise from HM, from other (normal) pregnancies or from other gestational events (such as ectopic pregnancies). The aim of this review is to outline current understating of the genetics and epigenetics of GTD and gestational CC and the link between the two diseases.