Evaluation of 68Ga-PSMA-11 PET/CT: a Phase 1 clinical study in Japanese patients with primary, recurrent, or suspected recurrent prostate cancer

• Published in: Annals of nuclear medicine Vol. 38; no. 8; pp. 587 - 595
• Main Authors: Inaki, Anri, Mizokami, Atsushi, Wakabayashi, Hiroshi, Izumi, Kouji, Kadono, Yoshifumi, Toyama, Tadashi, Takahara, Shizuko, Murayama, Toshinori, Kinuya, Seigo
• Format: Journal Article
• Language: English
• Published: Singapore Springer Nature Singapore 01.08.2024; Springer Nature B.V
• Subjects: Abnormalities; Adverse events; Antigens; Blood; EKG; Gallium; Gallium isotopes; Hematology; Imaging; Mean; Medical imaging; Medicine; Medicine & Public Health; Nuclear Medicine; Original; Original Article; Patients; Performance evaluation; Pharmaceuticals; Pharmacokinetics; Positron emission; Positron emission tomography; Prostate cancer; Prostate-specific antigen; Prostatectomy; Radiation dosage; Radiation therapy; Radioactivity; Radioisotopes; Radiology; Prostate-specific membrane antigen (PSMA); Ga-PSMA-11; PSMA PET; Prostate cancer; Positron emission imaging (PET)
• ISSN: 0914-7187; 1864-6433; 1864-6433
• DOI: 10.1007/s12149-024-01931-7

Background Prostate-specific membrane antigen (PSMA)-targeted radiopharmaceuticals allow whole-body imaging to detect prostate cancer (PC). Positron emission tomography imaging using gallium-68 ( 68 Ga)-PSMA-11 has been shown to have a favorable safety and tolerability profile and high diagnostic performance. The study evaluates the safety and pharmacokinetics of 68 Ga-PSMA-11 in Japanese patients with primary, recurrent, or suspected recurrent prostate cancer. Methods This single arm study enrolled Japanese patients with primary PC ( n  = 3), suspected recurrent PC following radical prostatectomy ( n  = 4), or suspected recurrent PC following radical radiotherapy ( n  = 3). All patients received a single intravenous dose of 68 Ga-PSMA-11 2.0 MBq/kg (±10%) followed by PSMA PET imaging and safety and pharmacokinetic evaluations. Based on the blood concentrations of 68 Ga-PSMA-11 and the radioactivity distribution rate in each organ/tissue, the absorbed doses in major organs/tissues and the whole-body effective dose were calculated by the Medical Internal Radiation Dose method. Results Ten patients were enrolled. Mean age was 73.3 ± 4.8 years, and median prostate-specific antigen was 8.250 ng/mL. Five patients (50%) experienced a total of 6 adverse events, and no grade ≥ 2 adverse events or serious adverse events were reported. No clinically significant changes in vital signs, haematology parameters, or blood chemistry or ECG abnormalities were observed. The estimated whole body effective dose of 68 Ga-PSMA-11 (mean ± standard deviation) was 2.524 × 10 –2  ± 2.546 × 10 –3  mSv/MBq. Time to maximum concentration (1.16 × 10 –4  ± 1.3 × 10 –5 % ID/mL) in whole blood was 2.15 ± 0.33 min. Conclusions 68 Ga-PSMA-11 has a favourable safety and tolerability profile in Japanese patients with primary, recurrent, or suspected recurrent prostate cancer, which is comparable to previous observations in other populations.