Impact of Obstructive Sleep Apnea in Surgical Patients: A Systematic Review

• Published in: Journal of clinical medicine Vol. 14; no. 14; p. 5095
• Main Authors: Titu, Ioana-Medeea, Vulturar, Damiana Maria, Chis, Ana Florica, Oprea, Alexandru, Manea, Alexandru, Todea, Doina Adina
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 17.07.2025; MDPI
• Subjects: Airway management; Anesthesia; Chronic obstructive pulmonary disease; Clinical medicine; Complications; Complications and side effects; Continuous positive airway pressure; Costs; Evidence; Gastrointestinal surgery; Medical personnel; Medical Subject Headings-MeSH; Mortality; Orthopedics; Otolaryngology; Postoperative period; Questionnaires; Sleep apnea; Sleep apnea syndromes; Surgery; Surgery, Experimental; Surgical research; Systematic Review; Trends; Romania; obstructive sleep apnea; CPAP; perioperative complications; preoperative screening
• ISSN: 2077-0383; 2077-0383
• DOI: 10.3390/jcm14145095

Background/Objectives: Obstructive sleep apnea is a prevalent, yet often underdiagnosed, condition characterized by recurrent upper airway obstruction during sleep, leading to significant perioperative risks in surgical patients. This systematic review aims to evaluate the incidence and impact of objectively diagnosed obstructive sleep apnea on postoperative outcomes across various surgical specialties—including bariatric, orthopedic, cardiac, and otorhinolaryngologic surgeries—and to assess the effectiveness of preoperative screening and perioperative management strategies. Methods: A comprehensive literature search of PubMed was conducted for studies published between January 2013 and December 2024, following Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Included studies involved adult surgical patients with OSA confirmed by polysomnography or respiratory polygraphy. Studies were assessed for methodological quality using the Oxford Centre for Evidence-Based Medicine Levels of Evidence framework. Results: The findings consistently indicated that obstructive sleep apnea significantly increases the risk of postoperative complications, such as respiratory depression, atrial fibrillation, acute kidney injury, delirium, and prolonged hospital stay. Continuous positive airway pressure therapy demonstrated a protective effect in bariatric and cardiac surgeries, though its effectiveness in orthopedic and otorhinolaryngologic contexts was inconsistent, largely due to adherence variability and limited implementation. Preoperative screening tools such as the STOP-BANG questionnaire were widely used, but their utility depended on integration with confirmatory diagnostics. Conclusions: Obstructive sleep apnea represents a significant, modifiable risk factor in surgical populations. Preoperative identification and risk-adapted perioperative management, including CPAP therapy and multimodal analgesia, may substantially reduce postoperative morbidity. However, further randomized trials and cost-effectiveness studies are needed to optimize care pathways and ensure consistent implementation across surgical disciplines.