Dietary Carbohydrates Impair Healthspan and Promote Mortality

• Published in: Cell metabolism Vol. 26; no. 4; pp. 585 - 587
• Main Authors: Ravichandran, Meenakshi, Grandl, Gerald, Ristow, Michael
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 03.10.2017
• Subjects: Acarbose - metabolism; Animals; Diet, Carbohydrate Loading - adverse effects; Diet, Ketogenic; Dietary Carbohydrates - adverse effects; Dietary Carbohydrates - metabolism; Dietary Fats - metabolism; Energy Intake; Glucose - metabolism; Glycolysis; Humans; Longevity; Prospective Studies; Sodium-Glucose Transporter 2 - metabolism
• ISSN: 1550-4131; 1932-7420; 1932-7420
• DOI: 10.1016/j.cmet.2017.09.011

The prospective cohort study, named PURE, found that in >135,000 participants from 18 countries, nutritive carbohydrates increase human mortality, whereas dietary fat reduces it, requesting a fundamental change of current nutritional guidelines. Experimental evidence from animal models provides synergizing mechanistic concepts as well as pharmacological options to mimic low-carb or ketogenic diets. The prospective cohort study, named PURE, found that in >135,000 participants from 18 countries, nutritive carbohydrates increase human mortality, whereas dietary fat reduces it, requesting a fundamental change of current nutritional guidelines. Experimental evidence from animal models provides synergizing mechanistic concepts as well as pharmacological options to mimic low-carb or ketogenic diets.