Chewing the Fat on Tumor Cell Metabolism

Tumor cells undergo a metabolic shift toward specific bioenergetic (glycolysis) and anabolic (protein and lipid synthesis) processes that promote rapid growth. Nomura et al. (2010) now demonstrate that an increase in monoacylglycerol lipase (MAGL) drives tumorigenesis through the lipolytic release a...

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Bibliographic Details
Published inCell Vol. 140; no. 1; pp. 28 - 30
Main Authors Yecies, Jessica L., Manning, Brendan D.
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 08.01.2010
Subjects
Fatty Acids - metabolism
Humans
Lipid Metabolism
Monoacylglycerol Lipases - metabolism
Neoplasms - metabolism
Online AccessGet full text
ISSN0092-8674
1097-4172
1097-4172
DOI10.1016/j.cell.2009.12.037

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Summary:Tumor cells undergo a metabolic shift toward specific bioenergetic (glycolysis) and anabolic (protein and lipid synthesis) processes that promote rapid growth. Nomura et al. (2010) now demonstrate that an increase in monoacylglycerol lipase (MAGL) drives tumorigenesis through the lipolytic release and remodeling of free fatty acids.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
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ObjectType-Commentary-1
ISSN:0092-8674
1097-4172
1097-4172
DOI:10.1016/j.cell.2009.12.037