Pulmonary vascular resistance and compliance in pulmonary blood flow alterations in children with congenital heart disease

• Published in: Heart and vessels Vol. 37; no. 7; pp. 1283 - 1289
• Main Authors: Iwaya, Yuka, Muneuchi, Jun, Sugitani, Yuichiro, Watanabe, Mamie
• Format: Journal Article
• Language: English
• Published: Tokyo Springer Japan 01.07.2022; Springer Nature B.V
• Subjects: Biomedical Engineering and Bioengineering; Blood circulation; Blood flow; Blood pressure; Cardiac Catheterization; Cardiac Surgery; Cardiology; Cardiovascular disease; Cardiovascular diseases; Catheterization; Child; Children; Compliance; Congenital diseases; Coronary artery disease; Coupling; Heart Defects, Congenital; Heart diseases; Hemodynamics; Humans; Hypertension, Pulmonary; Intubation; Medicine; Medicine & Public Health; Original Article; Pulmonary Artery; Pulmonary Circulation; Retrospective Studies; Vascular Resistance; Vascular Surgery; Ventricle; RC time; Heart failure; Pulmonary circulation; Pulmonary vascular capacitance; Pulmonary hypertension
• ISSN: 0910-8327; 1615-2573; 1615-2573
• DOI: 10.1007/s00380-021-02009-4

There is a unique hyperbolic relationship between pulmonary vascular resistance (Rp) and compliance (Cp); however, the characteristics of this coupling curve in pulmonary blood flow alterations remains unknown in children with congenital heart disease. We aimed to explore the Rp–Cp coupling and resistant-compliance (RC) time among them. We retrospectively reviewed catheterization data and calculated Rp and Cp in 217 subjects with ventricular septal defect. Median age and weight at catheterization were 2.8 (1.7–4.4) months and 4.3 (3.7–5.3) kg, respectively. Pulmonary hemodynamic parameters were as follows: mean pulmonary arterial pressure: 36 (28–43) mmHg; the amount of pulmonary blood flow (Qp): 14.2 (11.6–17.6) L/min/m 2 ; Rp: 1.95 (1.38–2.59) Wood unit m 2 ; Cp: 2.98 (2.42–3.88) mmHg/mL/m 2 ; and RC time: 0.35 (0.30–0.40) s. RC time remained unchanged according to alterations in Qp ( P  = 0.206); however, the relationship between logarithm transformations of Rp and Cp showed more steeper according to an increase in Qp. The pulmonary circulation depends upon Cp rather than Rp according to the degree of Qp despite the constancy in RC time. We should take both Rp and Cp into consideration when evaluating the pulmonary circulation among children with congenital heart disease.