Inhibitory effects of jujuboside A on EEG and hippocampal glutamate in hyperactive rat
In this study, the inhibitory effect ofjujuboside A (JuA) on a penicillin sodium (Na-PCN) induced hyperactivity model was investigated. Cortical EEG (electroencephalogram) and the concentration of hippocampal Glutamate (Glu) were monitored simultaneously in vivo as indicators of rat's excitator...
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| Published in | Journal of Zhejiang University. B. Science Vol. 6; no. 4; pp. 265 - 271 |
|---|---|
| Main Author | |
| Format | Journal Article |
| Language | English |
| Published |
China
Department of Biomedical Engineering, Zhejiang University, Hangzhou 310027, China
01.04.2005
Zhejiang University Press |
| Subjects | |
| Online Access | Get full text |
| ISSN | 1673-1581 1862-1783 |
| DOI | 10.1631/jzus.2005.B0265 |
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| Abstract | In this study, the inhibitory effect ofjujuboside A (JuA) on a penicillin sodium (Na-PCN) induced hyperactivity model was investigated. Cortical EEG (electroencephalogram) and the concentration of hippocampal Glutamate (Glu) were monitored simultaneously in vivo as indicators of rat's excitatory state. Power spectral density (PSD) and gravity frequency of PSD were calculated. JuA (0.05 g/L and 0.1 g/L) inhibited the EEG excitation effect caused by Na-PCN by increasing the power of δ1 and δ2 bands (P<0.01 vs model) and lowering the gravity frequency of PSD (P<0.01 vs model). JuA also remarkably reduced the Glu elevation induced by Na-PCN (P<0.05 vs model). Diazepam also depressed Glu concentration and lowered the gravity frequency, but it showed a different EEG pattern in increased β2-activity (P<0.01 vs model). EEG excitation caused by Na-PCN correlated with Glu elevation during the first hour. Neurophysiological inhibitory effects of JuA and diazepam were more persistent than their Glu inhibitoty effects. |
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| AbstractList | In this study, the inhibitory effect of jujuboside A (JuA) on a penicillin sodium (Na-PCN) induced hyperactivity model was investigated. Cortical EEG (electroencephalogram) and the concentration of hippocampal Glutamate (Glu) were monitored simultaneously in vivo as indicators of rat's excitatory state. Power spectral density (PSD) and gravity frequency of PSD were calculated. JuA (0.05 g/L and 0.1 g/L) inhibited the EEG excitation effect caused by Na-PCN by increasing the power of delta1 and delta2 bands (P<0.01 vs model) and lowering the gravity frequency of PSD (P<0.01 vs model). JuA also remarkably reduced the Glu elevation induced by Na-PCN (P<0.05 vs model). Diazepam also depressed Glu concentration and lowered the gravity frequency, but it showed a different EEG pattern in increased beta2-activity (P<0.01 vs model). EEG excitation caused by Na-PCN correlated with Glu elevation during the first hour. Neurophysiological inhibitory effects of JuA and diazepam were more persistent than their Glu inhibitory effects. In this study, the inhibitory effect of jujuboside A (JuA) on a penicillin sodium (Na-PCN) induced hyperactivity model was investigated. Cortical EEG (electroencephalogram) and the concentration of hippocampal Glutamate (Glu) were monitored simultaneously in vivo as indicators of rat's excitatory state. Power spectral density (PSD) and gravity frequency of PSD were calculated. JuA (0.05 g/L and 0.1 g/L) inhibited the EEG excitation effect caused by Na-PCN by increasing the power of delta1 and delta2 bands (P<0.01 vs model) and lowering the gravity frequency of PSD (P<0.01 vs model). JuA also remarkably reduced the Glu elevation induced by Na-PCN (P<0.05 vs model). Diazepam also depressed Glu concentration and lowered the gravity frequency, but it showed a different EEG pattern in increased beta2-activity (P<0.01 vs model). EEG excitation caused by Na-PCN correlated with Glu elevation during the first hour. Neurophysiological inhibitory effects of JuA and diazepam were more persistent than their Glu inhibitory effects.In this study, the inhibitory effect of jujuboside A (JuA) on a penicillin sodium (Na-PCN) induced hyperactivity model was investigated. Cortical EEG (electroencephalogram) and the concentration of hippocampal Glutamate (Glu) were monitored simultaneously in vivo as indicators of rat's excitatory state. Power spectral density (PSD) and gravity frequency of PSD were calculated. JuA (0.05 g/L and 0.1 g/L) inhibited the EEG excitation effect caused by Na-PCN by increasing the power of delta1 and delta2 bands (P<0.01 vs model) and lowering the gravity frequency of PSD (P<0.01 vs model). JuA also remarkably reduced the Glu elevation induced by Na-PCN (P<0.05 vs model). Diazepam also depressed Glu concentration and lowered the gravity frequency, but it showed a different EEG pattern in increased beta2-activity (P<0.01 vs model). EEG excitation caused by Na-PCN correlated with Glu elevation during the first hour. Neurophysiological inhibitory effects of JuA and diazepam were more persistent than their Glu inhibitory effects. R97; In this study, the inhibitory effect ofjujuboside A (JuA) on a penicillin sodium (Na-PCN) induced hyperactivity model was investigated. Cortical EEG (electroencephalogram) and the concentration of hippocampal Glutamate (Glu) were monitored simultaneously in vivo as indicators of rat's excitatory state. Power spectral density (PSD) and gravity frequency of PSD were calculated. JuA (0.05 g/L and 0.1 g/L) inhibited the EEG excitation effect caused by Na-PCN by increasing the power of δ1 and δ2bands (P＜0.01 vs model) and lowering the gravity frequency of PSD (P＜0.01 vs model). JuA also remarkably reduced the Glu elevation induced by Na-PCN (P＜0.05 vs model). Diazepam also depressed Glu concentration and lowered the gravity frequency,but it showed a different EEG pattern in increased β2-activity (P＜0.01 vs model). EEG excitation caused by Na-PCN correlated with Glu elevation during the first hour. Neurophysiological inhibitory effects of JuA and diazepam were more persistent than their Glu inhibitoty effects. In this study, the inhibitory effect ofjujuboside A (JuA) on a penicillin sodium (Na-PCN) induced hyperactivity model was investigated. Cortical EEG (electroencephalogram) and the concentration of hippocampal Glutamate (Glu) were monitored simultaneously in vivo as indicators of rat's excitatory state. Power spectral density (PSD) and gravity frequency of PSD were calculated. JuA (0.05 g/L and 0.1 g/L) inhibited the EEG excitation effect caused by Na-PCN by increasing the power of δ1 and δ2 bands (P<0.01 vs model) and lowering the gravity frequency of PSD (P<0.01 vs model). JuA also remarkably reduced the Glu elevation induced by Na-PCN (P<0.05 vs model). Diazepam also depressed Glu concentration and lowered the gravity frequency, but it showed a different EEG pattern in increased β2-activity (P<0.01 vs model). EEG excitation caused by Na-PCN correlated with Glu elevation during the first hour. Neurophysiological inhibitory effects of JuA and diazepam were more persistent than their Glu inhibitoty effects. In this study, the inhibitory effect of jujuboside A (JuA) on a penicillin sodium (Na-PCN) induced hyperactivity model was investigated. Cortical EEG (electroencephalogram) and the concentration of hippocampal Glutamate (Glu) were monitored simultaneously in vivo as indicators of rat's excitatory state. Power spectral density (PSD) and gravity frequency of PSD were calculated. JuA (0.05 g/L and 0.1 g/L) inhibited the EEG excitation effect caused by Na-PCN by increasing the power of delta 1 and delta 2 bands (P<0.01 vs model) and lowering the gravity frequency of PSD (P<0.01 vs model). JuA also remarkably reduced the Glu elevation induced by Na-PCN (P<0.05 vs model). Diazepam also depressed Glu concentration and lowered the gravity frequency, but it showed a different EEG pattern in increased beta 2-activity (P<0.01 vs model). EEG excitation caused by Na-PCN correlated with Glu elevation during the first hour. Neurophysiological inhibitory effects of JuA and diazepam were more persistent than their Glu inhibitoty effects. In this study, the inhibitory effect of jujuboside A (JuA) on a penicillin sodium (Na-PCN) induced hyperactivity model was investigated. Cortical EEG (electroencephalogram) and the concentration of hippocampal Glutamate (Glu) were monitored simultaneously in vivo as indicators of rat’s excitatory state. Power spectral density (PSD) and gravity frequency of PSD were calculated. JuA (0.05 g/L and 0.1 g/L) inhibited the EEG excitation effect caused by Na-PCN by increasing the power of δ1 and δ2 bands (P<0.01 vs model) and lowering the gravity frequency of PSD (P<0.01 vs model). JuA also remarkably reduced the Glu elevation induced by Na-PCN (P<0.05 vs model). Diazepam also depressed Glu concentration and lowered the gravity frequency, but it showed a different EEG pattern in increased β2-activity (P<0.01 vs model). EEG excitation caused by Na-PCN correlated with Glu elevation during the first hour. Neurophysiological inhibitory effects of JuA and diazepam were more persistent than their Glu inhibitoty effects. |
| Author | 卢英俊 周竣 张韶岷 张恒义 郑筱祥 |
| AuthorAffiliation | DepartmentofBiomedicalEngineering,ZhejiangUniversity,Hangzhou310027,China |
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| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/15754424$$D View this record in MEDLINE/PubMed |
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| Copyright | Copyright © Wanfang Data Co. Ltd. All Rights Reserved. Copyright © 2005, Journal of Zhejiang University Science 2005 |
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| Keywords | Power spectral density (PSD) Hyperactivity Penicillin sodium(Na-PCN) Glutamate (Glu) Electroencephalogram (EEG) Gravity frequency Diazepam Jujuboside A (JuA) |
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| References_xml | – reference: 7952066 - J Chromatogr B Biomed Appl. 1994 Jul 1;657(1):185-91 – reference: 10604604 - Epilepsy Res. 2000 Jan;38(1):33-44 – reference: 8956915 - Epilepsy Res. 1996 Nov;25(3):185-90 – reference: 11448097 - Cell Biol Int. 2001;25(7):593-8 – reference: 12357390 - Planta Med. 2002 Sep;68(9):799-803 – reference: 11888234 - Eur J Pain. 2002;6 Suppl A:3-9 – reference: 1805239 - Pharmacol Biochem Behav. 1991 Oct;40(2):351-7 – reference: 8415825 - Pharmacol Biochem Behav. 1993 Aug;45(4):857-63 – reference: 1192195 - Brain Res. 1975 Dec 26;100(3):589-97 – reference: 11889919 - Arch Ital Biol. 2002 Jan;140(1):13-30 – reference: 12962046 - Eksp Klin Farmakol. 2003 Mar-Apr;66(2):38-41 – reference: 3187565 - Sheng Li Xue Bao. 1988 Jun;40(3):308-13 – reference: 3685980 - Science. 1987 Nov 27;238(4831):1292-3 – reference: 8787032 - Prog Neurobiol. 1995 Dec;47(6):477-511 – reference: 6322040 - Neuropharmacology. 1983 Dec;22(12B):1459-70 – reference: 11027839 - Neurosci Lett. 2000 Oct 27;293(2):83-6 – reference: 11749788 - Acta Pharmacol Sin. 2001 Nov;22(11):986-90 – reference: 14531016 - Planta Med. 2003 Aug;69(8):692-5 |
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| Snippet | In this study, the inhibitory effect ofjujuboside A (JuA) on a penicillin sodium (Na-PCN) induced hyperactivity model was investigated. Cortical EEG... In this study, the inhibitory effect of jujuboside A (JuA) on a penicillin sodium (Na-PCN) induced hyperactivity model was investigated. Cortical EEG... R97; In this study, the inhibitory effect ofjujuboside A (JuA) on a penicillin sodium (Na-PCN) induced hyperactivity model was investigated. Cortical EEG... |
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| SubjectTerms | Animals Behavior, Animal - drug effects Biomedicine Diazepam - pharmacology Electroencephalography Glutamic Acid - metabolism Hippocampus - drug effects Hippocampus - metabolism Hippocampus - physiopathology Hyperkinesis - drug therapy Hyperkinesis - physiopathology Male Penicillins - pharmacology Rats Rats, Sprague-Dawley Saponins - pharmacology 大脑皮层 安定片 神经疾病 脑电图 谷氨酸盐 酸枣皂甙 青霉素钠 |
| Title | Inhibitory effects of jujuboside A on EEG and hippocampal glutamate in hyperactive rat |
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