Inhibitory effects of jujuboside A on EEG and hippocampal glutamate in hyperactive rat

• Published in: Journal of Zhejiang University. B. Science Vol. 6; no. 4; pp. 265 - 271
• Main Author: 卢英俊 周竣 张韶岷 张恒义 郑筱祥
• Format: Journal Article
• Language: English
• Published: China Department of Biomedical Engineering, Zhejiang University, Hangzhou 310027, China 01.04.2005; Zhejiang University Press
• Subjects: Animals; Behavior, Animal - drug effects; Biomedicine; Diazepam - pharmacology; Electroencephalography; Glutamic Acid - metabolism; Hippocampus - drug effects; Hippocampus - metabolism; Hippocampus - physiopathology; Hyperkinesis - drug therapy; Hyperkinesis - physiopathology; Male; Penicillins - pharmacology; Rats; Rats, Sprague-Dawley; Saponins - pharmacology; 大脑皮层; 安定片; 神经疾病; 脑电图; 谷氨酸盐; 酸枣皂甙; 青霉素钠; Power spectral density (PSD); Hyperactivity; Penicillin sodium(Na-PCN); Glutamate (Glu); Electroencephalogram (EEG); Gravity frequency; Diazepam; Jujuboside A (JuA)
• ISSN: 1673-1581; 1862-1783
• DOI: 10.1631/jzus.2005.B0265

In this study, the inhibitory effect ofjujuboside A (JuA) on a penicillin sodium (Na-PCN) induced hyperactivity model was investigated. Cortical EEG (electroencephalogram) and the concentration of hippocampal Glutamate (Glu) were monitored simultaneously in vivo as indicators of rat's excitatory state. Power spectral density (PSD) and gravity frequency of PSD were calculated. JuA (0.05 g/L and 0.1 g/L) inhibited the EEG excitation effect caused by Na-PCN by increasing the power of δ1 and δ2 bands (P<0.01 vs model) and lowering the gravity frequency of PSD (P<0.01 vs model). JuA also remarkably reduced the Glu elevation induced by Na-PCN (P<0.05 vs model). Diazepam also depressed Glu concentration and lowered the gravity frequency, but it showed a different EEG pattern in increased β2-activity (P<0.01 vs model). EEG excitation caused by Na-PCN correlated with Glu elevation during the first hour. Neurophysiological inhibitory effects of JuA and diazepam were more persistent than their Glu inhibitoty effects.