High serum copeptin may be a marker of an increased carotid intima-media thickness in asymptomatic patients with type 1 diabetes

• Published in: Journal of diabetes and its complications Vol. 36; no. 1; p. 108085
• Main Authors: Nattero-Chávez, Lía, Martínez-García, María Ángeles, Redondo López, Sandra, Fernández-Durán, Elena, Dorado Avendaño, Beatriz, Escobar-Morreale, Héctor F., Luque-Ramírez, Manuel
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.01.2022; Elsevier Limited
• Subjects: Asymptomatic; Atherosclerosis; Biomarkers; Body mass index; Cardiovascular disease; Carotid Artery Diseases - complications; Carotid Artery Diseases - diagnostic imaging; Carotid Intima-Media Thickness; carotid plaques; Cholesterol; Conflicts of interest; Consent; copeptin; Diabetes; Diabetes Mellitus, Type 1 - complications; Diabetes Mellitus, Type 2 - complications; Ethics; Fasting; Glycopeptides; Humans; Mortality; Patients; Population; Risk Factors; type 1 diabetes; Ultrasonic imaging; Values; Variables; vasopressin; T1DM; copeptin; cardiovascular disease; LowCp; type 1 diabetes; cIMT; vasopressin; WC; CP; carotid intima-media thickness; BP; PAD; LDL; Atherosclerosis; AVP; HighCp; carotid plaques; BMI
• ISSN: 1056-8727; 1873-460X; 1873-460X
• DOI: 10.1016/j.jdiacomp.2021.108085

We aimed to study the association of copeptin with carotid intima-media thickness in 60 patients with type 1 diabetes (T1DM-patients). Our results suggest that copeptin might improve the stratification of cardiovascular risk in T1DM-patients. Further research is needed to determine the value in identifying carotid disease of this biochemical marker. •Copeptin is associated with subclinical carotid atherosclerosis in T1DM-patients.•A potential pathophysiological link between copeptin and carotid disease is plausible.•Copeptin might improve the stratification of cardiovascular risk in patients with T1DM.•Further research is needed to determine the value in identifying carotid disease.