Lung Ultrasound and Microbubbles Enhance Aminoglycoside Efficacy and Delivery to the Lung in Escherichia coli –induced Pneumonia and Acute Respiratory Distress Syndrome

• Published in: American journal of respiratory and critical care medicine Vol. 198; no. 3; pp. 404 - 408
• Main Authors: Sugiyama, Michael G., Mintsopoulos, Victoria, Raheel, Hira, Goldenberg, Neil M., Batt, Jane E., Brochard, Laurent, Kuebler, Wolfgang M., Leong-Poi, Howard, Karshafian, Raffi, Lee, Warren L.
• Format: Journal Article
• Language: English
• Published: United States American Thoracic Society 01.08.2018
• Subjects: Aminoglycosides - administration & dosage; Animals; Anti-Bacterial Agents - administration & dosage; Antibiotics; Cavitation; Disease Models, Animal; Drug Delivery Systems - methods; Drug dosages; E coli; Edema; Escherichia coli Infections - drug therapy; Gentamicins - administration & dosage; Lungs; Male; Mice; Mice, Inbred C57BL; Microbubbles; Permeability; Pneumonia; Pneumonia, Bacterial - drug therapy; Respiratory distress syndrome; Respiratory Distress Syndrome, Adult - drug therapy; Ultrasonic imaging; Ultrasonic Waves
• ISSN: 1073-449X; 1535-4970; 1535-4970
• DOI: 10.1164/rccm.201711-2259LE

To the Editor: Acute respiratory distress syndrome (ARDS) is a devastating disorder characterized by lung microvascular leakage leading to pulmonary edema and hypoxemia (1). [...]developing an easy and safe method to increase the therapeutic index of aminoglycosides specifically in the lungs would be of great practical value. Thirty minutes after USMB, gentamicin concentrations in both BAL and lung tissue were significantly higher (at least twofold) in USMB-treated animals than in gentamicin-alone control animals (Figures 2B and 2C). [...]USMB enhanced antibiotic delivery and bacterial killing. Supported by the Canadian Institutes of Health Research (MOP 130564 [W.L.L.]), the Canada Foundation for Innovation (CFI 34769 [W.L.L.]), a Natural Sciences and Engineering Research Council (NSERC) of Canada Engage award (503493-16 [W.L.L.]), and an Ontario Centres of Excellence Voucher for Innovation and Productivity I award (OCE-VIP1 28176 [W.L.L.]).