Pathogenesis of Non-Hodgkin's Lymphoma

• Published in: Journal of clinical oncology Vol. 29; no. 14; pp. 1803 - 1811
• Main Authors: Nogai, Hendrik, Dörken, Bernd, Lenz, Georg
• Format: Journal Article
• Language: English
• Published: United States American Society of Clinical Oncology 10.05.2011
• Subjects: B-Lymphocytes - physiology; Humans; Lymphoma, Follicular - etiology; Lymphoma, Follicular - genetics; Lymphoma, Large B-Cell, Diffuse - etiology; Lymphoma, Large B-Cell, Diffuse - genetics; Lymphoma, Large B-Cell, Diffuse - mortality; Lymphoma, Mantle-Cell - etiology; Lymphoma, Mantle-Cell - genetics; Lymphoma, Non-Hodgkin - etiology; Lymphoma, Non-Hodgkin - genetics; NF-kappa B - physiology; Signal Transduction
• ISSN: 0732-183X; 1527-7755; 1527-7755
• DOI: 10.1200/JCO.2010.33.3252

The understanding of the molecular pathogenesis of non-Hodgkin's lymphomas (NHL) has significantly improved in recent years. Advances in molecular biology and genetics lead to the identification and characterization of several oncogenic pathways involved in lymphomagenesis. This knowledge will ultimately lead to improved diagnostic and therapeutic strategies for patients with NHL. This review summarizes current concepts of the molecular pathogenesis of the most common NHL subtypes, with a special emphasis on diffuse large B-cell lymphoma, the most common lymphoma subtype.