Quantitative detection using two‐dimension shell‐isolated nanoparticle film

• Published in: Journal of Raman spectroscopy Vol. 48; no. 7; pp. 919 - 924
• Main Authors: Yang, Jing‐Liang, Yang, Zhen‐Wei, Zhang, Yue‐Jiao, Ren, He, Zhang, Hua, Xu, Qing‐Chi, Panneerselvam, Rajapandiyan, Sivashanmugan, Kundan, Li, Jian‐Feng, Tian, Zhong‐Qun
• Format: Journal Article
• Language: English
• Published: Bognor Regis Wiley Subscription Services, Inc 01.07.2017
• Subjects: Ag@SiO2 nanoparticle; Melamine; Milk; Nanoparticles; quantitative analysis; Raman spectroscopy; Reproducibility; Sensitivity; shell‐isolated nanoparticle‐enhanced Raman spectroscopy; Silicon dioxide; Silver; Spectroscopy; Spectrum analysis; surface‐enhanced Raman spectroscopy
• ISSN: 0377-0486; 1097-4555
• DOI: 10.1002/jrs.5151

Surface‐enhanced Raman spectroscopy (SERS) can provide a fingerprint of molecules with ultrahigh sensitivity, down to the single‐molecule level. However, accurate quantitative detection in practical samples using SERS is still a great challenge. Herein, a highly uniform shell‐isolated Ag@SiO2 nanoparticle (Ag SHIN) monolayer film was prepared and employed as a substrate for the quantitative determination of melamine in milk samples through shell‐isolated nanoparticle‐enhanced Raman spectroscopy. The Ag SHIN film exhibits excellent reproducibility, high stability, as well as ultrahigh sensitivity with a limit of detection of 0.03 ppm. A linear relationship between the Raman intensity and the melamine concentration in a wide range (1 ppb to 5 ppm) was obtained. These results demonstrate that the Ag SHIN monolayer film is a promising and reliable substrate for the quantitative SERS analysis of practical samples. Copyright © 2017 John Wiley & Sons, Ltd. A highly uniform, reproducible, and stable shell‐isolated Ag@SiO2 nanoparticle monolayer film was prepared. It was employed as a substrate for the quantitative determination of melamine in milk samples through shell‐isolated nanoparticle‐enhanced Raman spectroscopy, and showed ultrahigh sensitivity with a limit of detection down to 0.03 ppm.