Regulation of Osteoclastogenesis and Bone Resorption by miRNAs

Osteoclasts are specialized bone-resorbing cells that contribute to physiological bone development and remodeling in bone metabolism throughout life. Abnormal production and activation of osteoclasts lead to excessive bone resorption in pathological conditions, such as in osteoporosis and in arthrit...

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Published inFrontiers in cell and developmental biology Vol. 9; p. 651161
Main Authors Inoue, Kazuki, Ng, Courtney, Xia, Yuhan, Zhao, Baohong
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Media S.A 18.06.2021
Subjects
bone resorption
Cell and Developmental Biology
miRNA
osteoclast
osteoporosis
rheumatoid arthritis
miRNA
osteoclast
osteoporosis
rheumatoid arthritis
bone resorption
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ISSN2296-634X
2296-634X
DOI10.3389/fcell.2021.651161

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Summary:Osteoclasts are specialized bone-resorbing cells that contribute to physiological bone development and remodeling in bone metabolism throughout life. Abnormal production and activation of osteoclasts lead to excessive bone resorption in pathological conditions, such as in osteoporosis and in arthritic diseases with bone destruction. Recent epigenetic studies have shed novel insight into the dogma of the regulation of gene expression. microRNAs belong to a category of epigenetic regulators, which post-transcriptionally regulate and silence target gene expression, and thereby control a variety of biological events. In this review, we discuss miRNA biogenesis, the mechanisms utilized by miRNAs, several miRNAs that play important roles in osteoclast differentiation, function, survival and osteoblast-to-osteoclast communication, and their translational potential and challenges in bone biology and skeletal diseases.
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This article was submitted to Cellular Biochemistry, a section of the journal Frontiers in Cell and Developmental Biology
Reviewed by: Jiake Xu, University of Western Australia, Australia; Yankel Gabet, Tel Aviv University, Israel
Edited by: Natalie A. Sims, University of Melbourne, Australia
ISSN:2296-634X
2296-634X
DOI:10.3389/fcell.2021.651161