Lactobacillus plantarum C29 Alleviates TNBS-Induced Memory Impairment in Mice

• Published in: Journal of microbiology and biotechnology Vol. 28; no. 1; pp. 175 - 179
• Main Authors: Lee, Hae-Ji, Jeong, Jin-Ju, Han, Myung Joo, Kim, Dong-Hyun
• Format: Journal Article
• Language: English
• Published: Korea (South) 한국미생물·생명공학회 28.01.2018
• Subjects: Administration, Oral; Animals; Lactobacillus plantarum - metabolism; Male; Memory Disorders - chemically induced; Memory Disorders - prevention & control; Mice, Inbred C57BL; Probiotics - administration & dosage; Treatment Outcome; Trinitrobenzenesulfonic Acid - toxicity; 생물학; Lactobacillus plantarum; colitis; memory impairment; gut microbiota
• ISSN: 1017-7825; 1738-8872
• DOI: 10.4014/jmb.1709.09042

In a preliminary study, C29 was found to suppress 2,4,6-trinitrobenzenesulfonic acid (TNBS)-induced colitis in mice. Therefore, to understand whether an anti-colitic probiotic C29 could attenuate memory impairment, we examined the effects of C29 on TNBS-induced memory impairment in mice. Orally administered C29 attenuated TNBS-induced memory impairment in mice in the Y-maze, noble object, and passive avoidance task tests. C29 treatment increased TNBS-suppressed hippocampal brain-derived neurotrophic factor expression and inhibited TNBS-induced hippocampal NF-kappaB activation and blood LPS levels. Moreover, C29 restored the TNBS-disturbed gut microbiota composition. These findings suggest that C29 can alleviate memory impairment presumably by restoring the gut microbiota composition.