Lactobacillus plantarum C29 Alleviates TNBS-Induced Memory Impairment in Mice

In a preliminary study, C29 was found to suppress 2,4,6-trinitrobenzenesulfonic acid (TNBS)-induced colitis in mice. Therefore, to understand whether an anti-colitic probiotic C29 could attenuate memory impairment, we examined the effects of C29 on TNBS-induced memory impairment in mice. Orally admi...

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Bibliographic Details
Published inJournal of microbiology and biotechnology Vol. 28; no. 1; pp. 175 - 179
Main Authors Lee, Hae-Ji, Jeong, Jin-Ju, Han, Myung Joo, Kim, Dong-Hyun
Format Journal Article
LanguageEnglish
Published Korea (South) 한국미생물·생명공학회 28.01.2018
Subjects
Administration, Oral
Animals
Lactobacillus plantarum - metabolism
Male
Memory Disorders - chemically induced
Memory Disorders - prevention & control
Mice, Inbred C57BL
Probiotics - administration & dosage
Treatment Outcome
Trinitrobenzenesulfonic Acid - toxicity
생물학
Lactobacillus plantarum
colitis
memory impairment
gut microbiota
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ISSN1017-7825
1738-8872
DOI10.4014/jmb.1709.09042

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Summary:In a preliminary study, C29 was found to suppress 2,4,6-trinitrobenzenesulfonic acid (TNBS)-induced colitis in mice. Therefore, to understand whether an anti-colitic probiotic C29 could attenuate memory impairment, we examined the effects of C29 on TNBS-induced memory impairment in mice. Orally administered C29 attenuated TNBS-induced memory impairment in mice in the Y-maze, noble object, and passive avoidance task tests. C29 treatment increased TNBS-suppressed hippocampal brain-derived neurotrophic factor expression and inhibited TNBS-induced hippocampal NF-kappaB activation and blood LPS levels. Moreover, C29 restored the TNBS-disturbed gut microbiota composition. These findings suggest that C29 can alleviate memory impairment presumably by restoring the gut microbiota composition.
ISSN:1017-7825
1738-8872
DOI:10.4014/jmb.1709.09042