Immune modulation properties of herbal plant leaves: Phyllanthus niruri aqueous extract on immune cells of tuberculosis patient - in vitro study

• Published in: Natural product research Vol. 32; no. 4; pp. 463 - 467
• Main Authors: Putri, Denise Utami, Rintiswati, Ning, Soesatyo, Marsetyawan HNE, Haryana, Sofia Mubarika
• Format: Journal Article
• Language: English
• Published: England Taylor & Francis 16.02.2018; Taylor & Francis Ltd
• Subjects: Adjuvants, Immunologic - pharmacology; Adult; Antioxidants - pharmacology; Cell proliferation; Cell Proliferation - drug effects; Dose-Response Relationship, Drug; Female; herbal plant; Humans; immune modulation; Immune system; Immunologic Factors - immunology; Immunologic Factors - pharmacology; Immunomodulation; Indonesia; Leukocytes (mononuclear); Leukocytes, Mononuclear - drug effects; Leukocytes, Mononuclear - immunology; Macrophages; Macrophages - drug effects; Macrophages - immunology; Male; Nitric oxide; Nitric Oxide - metabolism; Patients; Peripheral blood mononuclear cells; Phagocytes; phagocytic activity; Phagocytosis - drug effects; Phyllanthus - chemistry; Phyllanthus niruri; Plant extracts; Plant Extracts - administration & dosage; Plant Extracts - immunology; Plant Extracts - pharmacology; Plant Leaves - chemistry; Plants, Medicinal - chemistry; Tuberculosis; Tuberculosis, Pulmonary - blood; Tuberculosis, Pulmonary - immunology; Phyllanthus niruri; Tuberculosis; immune modulation; herbal plant; phagocytic activity
• ISSN: 1478-6419; 1478-6427; 1478-6427
• DOI: 10.1080/14786419.2017.1311888

Disease progression in Tuberculosis (TB) is dependent on host's immune system. Phyllanthus niruri, a traditional herb, has long been used to boost immune system in Indonesian society. This study aimed to observe the potential role of P. niruri in inducing immune cells activity in TB patients by in vitro approach. Peripheral blood mononuclear cells (PBMCs) and macrophages were collected from active pulmonary TB patients. After stimulation with graded doses of P. niruri aqueous extract, cell proliferation, phagocytic activity and nitric oxide (NO) release were analysed. P. niruri aqueous extract induced proliferation of PBMCs, increased NO release, and improved macrophages phagocytic activity. These effects were observed in a dose-dependent manner. This may lead to further research for the potential role of P. niruri as immunomodulatory adjuvant therapy for TB patients.