Erectile dysfunction, loss of libido and low sexual frequency increase the risk of cardiovascular disease in men with low testosterone

• Published in: The aging male Vol. 19; no. 2; pp. 96 - 101
• Main Authors: Ho, Chen-Hsun, Wu, Chia-Chang, Chen, Kuan-Chou, Jaw, Fu-Shan, Yu, Hong-Jeng, Liu, Shih-Ping
• Format: Journal Article
• Language: English
• Published: England Taylor & Francis 01.06.2016; Taylor & Francis Ltd
• Subjects: Cardiovascular disease; Cardiovascular Diseases - etiology; Erectile dysfunction; Erectile Dysfunction - complications; Eunuchism - complications; Framingham Risk Score; Humans; hypogonadism; libido; Libido - physiology; Logistic Models; Male; Men; Middle Aged; Regression analysis; Risk Factors; Sexual behavior; Sexual Behavior - physiology; Sexual disorders; Testosterone; Testosterone - deficiency; Testosterone; cardiovascular disease; hypogonadism; libido; Framingham Risk Score; erectile dysfunction
• ISSN: 1368-5538; 1473-0790; 1473-0790
• DOI: 10.3109/13685538.2015.1129400

Introduction: Testosterone deficiency increases the cardiovascular disease (CVD) risk. Aim: To evaluate the effect of erectile dysfunction (ED), sexual frequency and hypogonadal symptoms on CVD risk. Methods: A total of 395 hypogonadal men aged 45-74 years were surveyed using the Androgen Deficiency in the Aging Male and the International Index of Erectile Function. Main outcome measures: The 10-year CVD risk was measured with the Framingham Risk Score. Logistic regression was performed to obtain the odds ratios of sexual function and hypogonadal symptoms for a 10-year CVD risk ≥20% (high risk). Results: The mean age was 56.1 ± 6.7 years. The mean 10-year CVD risk of the whole cohort was 18.1% ± 11.4%, while 131 subjects (33.2%) were classified as high risk. Logistic regression revealed that ED severity was associated with CVD risk [OR = 2.37 (CI 1.24-4.51) for mild-to-moderate ED, OR = 4.39 (1.78-8.43) for moderate ED and OR = 12.81 (4.65-26.11) for severe ED]. Compared to sexual frequency <1 per month, sexual frequency ≥4 decreased the risk of high CVD risk [OR = 0.35 (0.23-0.780)]. Loss of libido [OR = 2.95 (1.91-4.12)] and less strong erection [OR = 3.87 (CI 2.11-4.95)] increased the risk of high CVD risk. All remained significant after adjustment for age and testosterone. Conclusions: ED, decreased sexual frequency and loss of libido predict a high 10-year CVD risk in hypogonadal men.