Design, synthesis and anticoccidial activity of a series of 3-(2-(2-methoxyphenyl)-2-oxoethyl) quinazolinone derivatives
A series of 3-(2-(2-methoxyphenyl)-2-oxoethyl) quinazolinone derivatives were designed and synthesized as anticoccidial agents by modifying the quinazoline ring of febrifugine. All the compounds were biologically evaluated according to the ACI method, and four of them exhibited anticoccidial activit...
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| Published in | Pesticide biochemistry and physiology Vol. 97; no. 3; pp. 194 - 198 |
|---|---|
| Main Authors | , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Amsterdam
Elsevier Inc
01.07.2010
Elsevier |
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| Online Access | Get full text |
| ISSN | 0048-3575 1095-9939 |
| DOI | 10.1016/j.pestbp.2010.02.001 |
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| Abstract | A series of 3-(2-(2-methoxyphenyl)-2-oxoethyl) quinazolinone derivatives were designed and synthesized as anticoccidial agents by modifying the quinazoline ring of febrifugine. All the compounds were biologically evaluated according to the ACI method, and four of them exhibited anticoccidial activity against
Eimeria tenella in the chicken at a dose of 9
mg/kg. Compound
5e shows ACI value at 173.2 and is as potent as decoquinate. These data suggest that
5e possesses high anticoccidial activity and may serve as a lead compound for the development of anticoccidial drugs in the future. |
|---|---|
| AbstractList | A series of 3-(2-(2-methoxyphenyl)-2-oxoethyl) quinazolinone derivatives were designed and synthesized as anticoccidial agents by modifying the quinazoline ring of febrifugine. All the compounds were biologically evaluated according to the ACI method, and four of them exhibited anticoccidial activity against
Eimeria tenella in the chicken at a dose of 9
mg/kg. Compound
5e shows ACI value at 173.2 and is as potent as decoquinate. These data suggest that
5e possesses high anticoccidial activity and may serve as a lead compound for the development of anticoccidial drugs in the future. A series of 3-(2-(2-methoxyphenyl)-2-oxoethyl) quinazolinone derivatives were designed and synthesized as anticoccidial agents by modifying the quinazoline ring of febrifugine. All the compounds were biologically evaluated according to the ACI method, and four of them exhibited anticoccidial activity against Eimeria tenella in the chicken at a dose of 9 mg/kg. Compound 5e shows ACI value at 173.2 and is as potent as decoquinate. These data suggest that 5e possesses high anticoccidial activity and may serve as a lead compound for the development of anticoccidial drugs in the future. |
| Author | Li, Jun Weng, Yabiao Li, XiaoFeng You, Junhui You, Rong Ye, Changwen Wang, Yuliang |
| Author_xml | – sequence: 1 givenname: Changwen surname: Ye fullname: Ye, Changwen organization: Department of Chemical Engineering, Sichuan University, Chengdu 610064, PR China – sequence: 2 givenname: Junhui surname: You fullname: You, Junhui organization: Department of Chemistry, Sichuan University, Chengdu 610064, PR China – sequence: 3 givenname: XiaoFeng surname: Li fullname: Li, XiaoFeng organization: National Hazardous Chemicals Quality Supervision and Inspection Center, Chengdu 610021, PR China – sequence: 4 givenname: Rong surname: You fullname: You, Rong organization: National Hazardous Chemicals Quality Supervision and Inspection Center, Chengdu 610021, PR China – sequence: 5 givenname: Yabiao surname: Weng fullname: Weng, Yabiao organization: Department of Veterinary Medicine, South China Agricultural University, Guangzhou 510642, PR China – sequence: 6 givenname: Jun surname: Li fullname: Li, Jun organization: Department of Chemical Engineering, Sichuan University, Chengdu 610064, PR China – sequence: 7 givenname: Yuliang surname: Wang fullname: Wang, Yuliang email: Chemwang2000@163.com organization: Department of Chemistry, Sichuan University, Chengdu 610064, PR China |
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| Cites_doi | 10.1016/j.bmcl.2006.01.009 10.1016/j.vetpar.2003.12.009 10.1016/j.pestbp.2008.11.005 10.1016/S0040-4020(01)00053-9 10.1021/np0700523 10.1016/j.aca.2004.08.017 10.1021/jo01135a017 10.1016/S0034-5288(97)90142-9 10.1016/j.bmcl.2008.01.104 10.1080/03079459708419208 10.1016/j.ejmech.2007.02.006 10.1016/j.ejmech.2005.09.010 10.3998/ark.5550190.0009.h01 10.1016/j.vetpar.2006.01.056 10.1021/jo01135a014 10.1016/S0040-4020(03)00139-X 10.1016/j.bmcl.2007.05.053 |
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| Keywords | Anticoccidial index method Eimeria tenella 3-(2-(2-Methoxyphenyl)-2-oxoethyl) quinazolinone Synthesis Anticoccidial activities Pesticides quinazolinone Index Method 3-(2-(2-Methoxyphenyl)-2-oxoethyl) |
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| SubjectTerms | 3-(2-(2-Methoxyphenyl)-2-oxoethyl) quinazolinone Anticoccidial activities Anticoccidial index method Biological and medical sciences chickens coccidiostats Eimeria tenella Synthesis |
| Title | Design, synthesis and anticoccidial activity of a series of 3-(2-(2-methoxyphenyl)-2-oxoethyl) quinazolinone derivatives |
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