Design, synthesis and anticoccidial activity of a series of 3-(2-(2-methoxyphenyl)-2-oxoethyl) quinazolinone derivatives

• Published in: Pesticide biochemistry and physiology Vol. 97; no. 3; pp. 194 - 198
• Main Authors: Ye, Changwen, You, Junhui, Li, XiaoFeng, You, Rong, Weng, Yabiao, Li, Jun, Wang, Yuliang
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier Inc 01.07.2010; Elsevier
• Subjects: 3-(2-(2-Methoxyphenyl)-2-oxoethyl) quinazolinone; Anticoccidial activities; Anticoccidial index method; Biological and medical sciences; chickens; coccidiostats; Eimeria tenella; Synthesis; Anticoccidial index method; Eimeria tenella; 3-(2-(2-Methoxyphenyl)-2-oxoethyl) quinazolinone; Synthesis; Anticoccidial activities; Pesticides; quinazolinone; Index; Method; 3-(2-(2-Methoxyphenyl)-2-oxoethyl)
• ISSN: 0048-3575; 1095-9939
• DOI: 10.1016/j.pestbp.2010.02.001

A series of 3-(2-(2-methoxyphenyl)-2-oxoethyl) quinazolinone derivatives were designed and synthesized as anticoccidial agents by modifying the quinazoline ring of febrifugine. All the compounds were biologically evaluated according to the ACI method, and four of them exhibited anticoccidial activity against Eimeria tenella in the chicken at a dose of 9 mg/kg. Compound 5e shows ACI value at 173.2 and is as potent as decoquinate. These data suggest that 5e possesses high anticoccidial activity and may serve as a lead compound for the development of anticoccidial drugs in the future.