Peripheral blood levels of CXCL10 are a useful marker for diabetic polyneuropathy in subjects with type 2 diabetes

• Published in: International journal of clinical practice (Esher) Vol. 75; no. 8; pp. e14302 - n/a
• Main Authors: Ascaso, Pilar, Palanca, Ana, Martinez‐Hervás, Sergio, Sanz, María Jesús, Ascaso, Juan F., Piqueras, Laura, Real, José T.
• Format: Journal Article
• Language: English
• Published: India John Wiley & Sons, Inc 01.08.2021
• Subjects: Biomarkers; Blood levels; Chemokine CXCL10; Chemokines; CXCL10 protein; CXCL11 protein; Diabetes; Diabetes mellitus (non-insulin dependent); Diabetes Mellitus, Type 2 - complications; Diabetic Neuropathies; Diabetic neuropathy; Humans; Ischemia; Morbidity; Peripheral blood; Peripheral neuropathy; Pilot Projects; Plasma levels; Polyneuropathy; Regeneration; Risk Factors; Serum levels
• ISSN: 1368-5031; 1742-1241; 1742-1241
• DOI: 10.1111/ijcp.14302

Background Diabetic peripheral neuropathy (DPN) is a chronic complication of diabetes mellitus associated with high morbidity and mortality. Major risk factors for DPN include metabolic changes, duration of diabetes, nerve ischaemia and derangements in regeneration and nerve repair programmes. Chemokines have been previously implicated in the pathogenesis of various neuropathies and neuropathic pain processes. The aim of this pilot study was to evaluate the association between the plasma levels of chemokines (CXCL9, CXCL10 and CXCL11) in the presence of DPN in a cohort of type 2 diabetes (T2D) patients. Materials and methods We studied 73 patients with T2D: 36 with DPN and 37 without DPN. DPN was established through the Semmes‐Weinstein test (SW). Plasma levels of circulating chemokines CXCL9, CXCL10 and CXCL11 were determined using DuoSet ELISA kits (Abingdon, UK). Results We found that levels of CXCL10 were significantly higher in patients with DPN than amongst patients without DPN (57.6 ± 38.3 vs 38.1 ± 33.4 pg/mL, respectively; P = .034). Serum levels of chemokine CXCL9 were also higher amongst patients with DPN but did not reach a statistical significance (188.1 ± 72.7 and 150.4 ± 83.6 pg/mL, respectively, P = .06). Conclusions Increased circulating levels of CXCL10 were associated with DPN in T2D patients, suggesting a role of this chemokine in the DPN. Determination of CXCL10 levels could be used as a marker for the early detection and implementation of therapeutic strategies in order to reverse and prevent the DPN.