Polymer-Supported Copper(I) Catalysts for the Experimentally Simplified Azide-Alkyne Cycloaddition

Tris‐(benzyltriazolylmethyl)amine (TBTA), a widely used ligand for the copper‐catalyzed azide‐alkyne cycloaddition, has been immobilized on a TentaGel resin. Once loaded with copper(I), the resulting air‐stable complex acts as an efficient catalyst for the azide‐alkyne cycloaddition reaction and pre...

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Bibliographic Details
Published inQSAR & combinatorial science Vol. 26; no. 11-12; pp. 1274 - 1279
Main Authors Chan, Timothy R., Fokin, Valery V.
Format Journal Article
LanguageEnglish
Published Weinheim WILEY-VCH Verlag 01.12.2007
WILEY‐VCH Verlag
Subjects
alkynes
azides
catalysis
click chemistry
cycloaddition
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ISSN1611-020X
1611-0218
DOI10.1002/qsar.200740131

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Summary:Tris‐(benzyltriazolylmethyl)amine (TBTA), a widely used ligand for the copper‐catalyzed azide‐alkyne cycloaddition, has been immobilized on a TentaGel resin. Once loaded with copper(I), the resulting air‐stable complex acts as an efficient catalyst for the azide‐alkyne cycloaddition reaction and prevents contamination of products by copper salts. The immobilized TBTA ligand should find immediate use in the parallel synthesis of compounds for direct screening.
Bibliography:ark:/67375/WNG-CB4RDVGB-H
istex:E42F93CCB8458E95AF4ABA50BC4BC09586221207
ArticleID:QSAR200740131
ISSN:1611-020X
1611-0218
DOI:10.1002/qsar.200740131