Responses of human motoneurons to high-frequency stimulation of Ia afferents
This study was designed to extend to humans the findings of classical studies on anesthetized cats, which have examined the discharge of spinal motoneurons in response to high‐frequency stimulus trains delivered to Ia afferents. Experiments were conducted on the monosynaptic pathway in the flexor ca...
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| Published in | Muscle & nerve Vol. 38; no. 6; pp. 1604 - 1615 |
|---|---|
| Main Authors | , |
| Format | Journal Article |
| Language | English |
| Published |
Hoboken
Wiley Subscription Services, Inc., A Wiley Company
01.12.2008
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| Subjects | |
| Online Access | Get full text |
| ISSN | 0148-639X 1097-4598 |
| DOI | 10.1002/mus.21184 |
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| Abstract | This study was designed to extend to humans the findings of classical studies on anesthetized cats, which have examined the discharge of spinal motoneurons in response to high‐frequency stimulus trains delivered to Ia afferents. Experiments were conducted on the monosynaptic pathway in the flexor carpi radialis (FCR) and soleus muscles. Subjects maintained a rhythmic discharge of a single motor unit (SMU) in either the FCR or soleus while homonymous Ia afferents were stimulated with either a single‐ or multipulse train. An n@IPI stimulus train had n pulses (n = 2–4) and an interpulse interval (IPI) of 1–8 ms. For each condition and motor unit, surface electromyographic (EMG) activity was averaged, and peristimulus–time histograms (PSTHs) were constructed for the SMU. The magnitude of the EMG was high for IPI = 1 ms, low for IPI = 2–3 ms, and high for IPI = 4–8 ms. SMU responses showed a similar pattern, which indicated that the increased EMG response was due to the presence of multiple peaks in a PSTH. The key results indicate that: (1) a short, high‐frequency stimulus train enhances the discharge probability of a motoneuron above that observed with a single pulse; and (2) the increased motoneuron responses are significantly greater for the FCR than for the soleus muscle. © 2008 Wiley Periodicals, Inc. Muscle Nerve 38: 1604–1615, 2008 |
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| AbstractList | This study was designed to extend to humans the findings of classical studies on anesthetized cats, which have examined the discharge of spinal motoneurons in response to high‐frequency stimulus trains delivered to Ia afferents. Experiments were conducted on the monosynaptic pathway in the flexor carpi radialis (FCR) and soleus muscles. Subjects maintained a rhythmic discharge of a single motor unit (SMU) in either the FCR or soleus while homonymous Ia afferents were stimulated with either a single‐ or multipulse train. An n@IPI stimulus train had n pulses (n = 2–4) and an interpulse interval (IPI) of 1–8 ms. For each condition and motor unit, surface electromyographic (EMG) activity was averaged, and peristimulus–time histograms (PSTHs) were constructed for the SMU. The magnitude of the EMG was high for IPI = 1 ms, low for IPI = 2–3 ms, and high for IPI = 4–8 ms. SMU responses showed a similar pattern, which indicated that the increased EMG response was due to the presence of multiple peaks in a PSTH. The key results indicate that: (1) a short, high‐frequency stimulus train enhances the discharge probability of a motoneuron above that observed with a single pulse; and (2) the increased motoneuron responses are significantly greater for the FCR than for the soleus muscle. © 2008 Wiley Periodicals, Inc. Muscle Nerve 38: 1604–1615, 2008 This study was designed to extend to humans the findings of classical studies on anesthetized cats, which have examined the discharge of spinal motoneurons in response to high‐frequency stimulus trains delivered to Ia afferents. Experiments were conducted on the monosynaptic pathway in the flexor carpi radialis (FCR) and soleus muscles. Subjects maintained a rhythmic discharge of a single motor unit (SMU) in either the FCR or soleus while homonymous Ia afferents were stimulated with either a single‐ or multipulse train. An n @IPI stimulus train had n pulses ( n = 2–4) and an interpulse interval (IPI) of 1–8 ms. For each condition and motor unit, surface electromyographic (EMG) activity was averaged, and peristimulus–time histograms (PSTHs) were constructed for the SMU. The magnitude of the EMG was high for IPI = 1 ms, low for IPI = 2–3 ms, and high for IPI = 4–8 ms. SMU responses showed a similar pattern, which indicated that the increased EMG response was due to the presence of multiple peaks in a PSTH. The key results indicate that: (1) a short, high‐frequency stimulus train enhances the discharge probability of a motoneuron above that observed with a single pulse; and (2) the increased motoneuron responses are significantly greater for the FCR than for the soleus muscle. © 2008 Wiley Periodicals, Inc. Muscle Nerve 38: 1604–1615, 2008 This study was designed to extend to humans the findings of classical studies on anesthetized cats, which have examined the discharge of spinal motoneurons in response to high-frequency stimulus trains delivered to Ia afferents. Experiments were conducted on the monosynaptic pathway in the flexor carpi radialis (FCR) and soleus muscles. Subjects maintained a rhythmic discharge of a single motor unit (SMU) in either the FCR or soleus while homonymous Ia afferents were stimulated with either a single- or multipulse train. An n@IPI stimulus train had n pulses (n = 2-4) and an interpulse interval (IPI) of 1-8 ms. For each condition and motor unit, surface electromyographic (EMG) activity was averaged, and peristimulus-time histograms (PSTHs) were constructed for the SMU. The magnitude of the EMG was high for IPI = 1 ms, low for IPI = 2-3 ms, and high for IPI = 4-8 ms. SMU responses showed a similar pattern, which indicated that the increased EMG response was due to the presence of multiple peaks in a PSTH. The key results indicate that: (1) a short, high-frequency stimulus train enhances the discharge probability of a motoneuron above that observed with a single pulse; and (2) the increased motoneuron responses are significantly greater for the FCR than for the soleus muscle. This study was designed to extend to humans the findings of classical studies on anesthetized cats, which have examined the discharge of spinal motoneurons in response to high-frequency stimulus trains delivered to Ia afferents. Experiments were conducted on the monosynaptic pathway in the flexor carpi radialis (FCR) and soleus muscles. Subjects maintained a rhythmic discharge of a single motor unit (SMU) in either the FCR or soleus while homonymous Ia afferents were stimulated with either a single- or multipulse train. An nPI stimulus train had n pulses (n = 2-4) and an interpulse interval (IPI) of 1-8 ms. For each condition and motor unit, surface electromyographic (EMG) activity was averaged, and peristimulus-time histograms (PSTHs) were constructed for the SMU. The magnitude of the EMG was high for IPI = 1 ms, low for IPI = 2-3 ms, and high for IPI = 4-8 ms. SMU responses showed a similar pattern, which indicated that the increased EMG response was due to the presence of multiple peaks in a PSTH. The key results indicate that: (1) a short, high-frequency stimulus train enhances the discharge probability of a motoneuron above that observed with a single pulse; and (2) the increased motoneuron responses are significantly greater for the FCR than for the soleus muscle. This study was designed to extend to humans the findings of classical studies on anesthetized cats, which have examined the discharge of spinal motoneurons in response to high-frequency stimulus trains delivered to Ia afferents. Experiments were conducted on the monosynaptic pathway in the flexor carpi radialis (FCR) and soleus muscles. Subjects maintained a rhythmic discharge of a single motor unit (SMU) in either the FCR or soleus while homonymous Ia afferents were stimulated with either a single- or multipulse train. An n@IPI stimulus train had n pulses (n = 2-4) and an interpulse interval (IPI) of 1-8 ms. For each condition and motor unit, surface electromyographic (EMG) activity was averaged, and peristimulus-time histograms (PSTHs) were constructed for the SMU. The magnitude of the EMG was high for IPI = 1 ms, low for IPI = 2-3 ms, and high for IPI = 4-8 ms. SMU responses showed a similar pattern, which indicated that the increased EMG response was due to the presence of multiple peaks in a PSTH. The key results indicate that: (1) a short, high-frequency stimulus train enhances the discharge probability of a motoneuron above that observed with a single pulse; and (2) the increased motoneuron responses are significantly greater for the FCR than for the soleus muscle.This study was designed to extend to humans the findings of classical studies on anesthetized cats, which have examined the discharge of spinal motoneurons in response to high-frequency stimulus trains delivered to Ia afferents. Experiments were conducted on the monosynaptic pathway in the flexor carpi radialis (FCR) and soleus muscles. Subjects maintained a rhythmic discharge of a single motor unit (SMU) in either the FCR or soleus while homonymous Ia afferents were stimulated with either a single- or multipulse train. An n@IPI stimulus train had n pulses (n = 2-4) and an interpulse interval (IPI) of 1-8 ms. For each condition and motor unit, surface electromyographic (EMG) activity was averaged, and peristimulus-time histograms (PSTHs) were constructed for the SMU. The magnitude of the EMG was high for IPI = 1 ms, low for IPI = 2-3 ms, and high for IPI = 4-8 ms. SMU responses showed a similar pattern, which indicated that the increased EMG response was due to the presence of multiple peaks in a PSTH. The key results indicate that: (1) a short, high-frequency stimulus train enhances the discharge probability of a motoneuron above that observed with a single pulse; and (2) the increased motoneuron responses are significantly greater for the FCR than for the soleus muscle. |
| Author | Bawa, Parveen Chalmers, Gordon |
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| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/19016548$$D View this record in MEDLINE/PubMed |
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| CitedBy_id | crossref_primary_10_3389_fnhum_2014_01002 crossref_primary_10_1016_j_clinph_2009_08_011 crossref_primary_10_1038_s41593_018_0262_6 crossref_primary_10_1371_journal_pone_0222849 crossref_primary_10_1371_journal_pone_0065937 crossref_primary_10_1371_journal_pone_0161614 |
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| SubjectTerms | Adult Animals Cats Electric Stimulation Electromyography EPSP Excitatory Postsynaptic Potentials - physiology Female H-reflex high-frequency stimulus Humans Male Middle Aged Motor Neurons - physiology motor unit Muscle Fibers, Skeletal - physiology Neurons, Afferent - physiology spindle afferents Young Adult |
| Title | Responses of human motoneurons to high-frequency stimulation of Ia afferents |
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