Comparison of variability in cardiorespiratory measurements following desflurane anesthesia at a multiple of the minimum alveolar concentration for each dog versus a multiple of a single predetermined minimum alveolar concentration for all dogs in a group

• Published in: American journal of veterinary research Vol. 67; no. 12; pp. 1956 - 1961
• Main Authors: Pypendop, B.H, Ilkiw, J.E
• Format: Journal Article
• Language: English
• Published: United States 01.12.2006
• Subjects: administration & dosage; analogs & derivatives; anesthesia; anesthetics; Anesthetics, Inhalation; Anesthetics, Inhalation - administration & dosage; Anesthetics, Inhalation - pharmacology; Animals; arteries; blood gases; blood pH; blood pressure; Blood Pressure - drug effects; blood veins; breathing; cardiac output; desflurane; dogs; Dogs - physiology; drug effects; Female; heart rate; Heart Rate - drug effects; Isoflurane; Isoflurane - administration & dosage; Isoflurane - analogs & derivatives; Isoflurane - pharmacology; Male; minimum alveolar concentration; pets; pharmacology; physiology; pulmonary alveoli; Pulmonary Alveoli - physiology; pulmonary artery; Respiration; Respiration - drug effects; respiratory rate
• ISSN: 0002-9645; 1943-5681
• DOI: 10.2460/ajvr.67.12.1956

Objective —To determine whether the variability of cardiorespiratory measurements is smaller when administering desflurane at a multiple of the individual's minimum alveolar concentration (MAC) or at a predetermined, identical concentration in all subjects. Animals —10 dogs. Procedures —Desflurane was administered at 1.5 times the individual's MAC (iMAC) and 1.5 times the group's MAC (gMAC). The order of concentrations was randomly selected. Heart rate, respiratory rate, arterial blood pressure, central venous pressure, mean pulmonary artery pressure, pulmonary artery occlusion pressure, arterial and mixed-venous blood gas tensions and pH, and cardiac output were measured. The desflurane concentration required to achieve a mean arterial pressure (MAP) of 60 mm Hg was then determined. Finally, the desflurane concentration required to achieve an end-tidal PCO 2 of 55 mm Hg was measured. Results —Variances when administering 1.5 iMAC or 1.5 gMAC were not significantly different for any variable studied. Differences between the MAC multiples needed to reach an MAP of 60 mm Hg and the mean of the sample were significantly larger when gMAC was used, compared with iMAC, indicating that a multiple of iMAC better predicted the concentration resulting in a MAP of 60 mm Hg. Conclusions and Clinical Relevance —Results suggest that, in a small group of dogs, variability in cardiorespiratory measurements among dogs is unlikely to differ whether an inhalant anesthetic is administered at a multiple of the iMAC in each dog or at an identical gMAC in all dogs.