Evaluation of CYP2C9 - and VKORC1 -Based PharMacogenetic Algorithm for Warfarin dose in Gaza-Palestine

To evaluate applicability of , and based algorithm to predict warfarin stable dose (WSD) in a group of Palestinian patients. Warfarin doses were retrospectively calculated for 101 Palestinian patients under warfarin therapy using three models. Performance of the three models was assessed in 47 patie...

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Bibliographic Details
Published inFuture science OA Vol. 4; no. 3; p. FSO276
Main Authors Ayesh, Basim Mohammad, Abu Shaaban, Ahmed Shaker, Abed, Abdalla Asaf
Format Journal Article
LanguageEnglish
Published England Future Science Ltd 01.03.2018
Subjects
VKORC1
allelic frequency
CYP2C9
IWPC algorithm
Gaza strip
pharmacogenetics
vitamin K antagonist
warfarin
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ISSN2056-5623
2056-5623
DOI10.4155/fsoa-2017-0112

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Summary:To evaluate applicability of , and based algorithm to predict warfarin stable dose (WSD) in a group of Palestinian patients. Warfarin doses were retrospectively calculated for 101 Palestinian patients under warfarin therapy using three models. Performance of the three models was assessed in 47 patients found to take WSD. Frequency of , and alleles is 13.6, 0.0 and 46.5% respectively. The international warfarin pharmacogenetics consortium algorithm was more reliable (MAE = 8.9 ± 1.4; R  = 0.350) than both the clinical algorithm (MAE = 10.4 ± 1.4; R  = 0.128;) and the fixed-dose algorithm (MAE = 11.1 ± 1.7). The international warfarin pharmacogenetics consortium algorithm can be reliably applied for predicting the WSD in Palestinian population.
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ISSN:2056-5623
2056-5623
DOI:10.4155/fsoa-2017-0112