A Preliminary Link between Hydroxylated Metabolites of Polychlorinated Biphenyls and Free Thyroxin in Humans

• Published in: International journal of environmental research and public health Vol. 13; no. 4; p. 421
• Main Authors: Dirinck, Eveline, Dirtu, Alin, Malarvannan, Govindan, Covaci, Adrian, Jorens, Philippe, Van Gaal, Luc
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI 13.04.2016
• Subjects: Adolescent; Adult; Age Factors; Aged; Aged, 80 and over; Body Composition; Female; Humans; Hydroxylation; Male; Middle Aged; Polychlorinated Biphenyls - blood; Polychlorinated Biphenyls - pharmacokinetics; Sex Factors; Smoking - epidemiology; Thyroid Gland - metabolism; Thyroid Hormones - blood; Thyrotropin - blood; Thyroxine - blood; Young Adult; thyroid function; polychlorinated biphenyls; hydroxylated polychlorinated biphenyls; endocrine disrupters; human
• ISSN: 1660-4601; 1661-7827; 1660-4601
• DOI: 10.3390/ijerph13040421

Background: Polychlorinated biphenyls (PCBs) and their hydroxylated metabolites (HO-PCBs) interfere with thyroid hormone action both in vitro and in vivo. However, epidemiologic studies on the link between PCB exposure and thyroid function have yielded discordant results, while very few data are available for HO-PCBs. Objectives: Our study aimed at investigating the relationship between clinically available markers of thyroid metabolism and serum levels of both PCBs and HO-PCBs. Subjects and Methods: In a group of 180 subjects, thyroid-stimulating hormone (TSH) and free thyroxin (fT4), 29 PCBs (expressed both in lipid weight and in wet weight) and 18 HO-PCBs were measured in serum. Results: In regression models, adjusted for gender, age, current smoking behavior, BMI and total lipid levels, serum levels of 3HO-PCB118 and 3HO-PCB180, and PCB95lw, PCB99lw and PCB149lw were independent, significant predictors of fT4. A stepwise, multiple regression with gender, age, current smoking behavior, BMI and total lipid levels and all five previously identified significant compounds retained age, BMI, PCB95lw, PCB99lw and 3HO-PCB180 as significant predictors of fT4. TSH levels were not predicted by serum levels of any of the PCBs or HO-PCBs. Conclusions: Our study indicates that in vivo, circulating fT4 levels can be linked to serum levels of several PCBs and hydroxylated PCB metabolites.