Metabolic Syndrome and Colorectal Cancer Risk: Results of Propensity Score-Based Analyses in a Community-Based Cohort Study

• Published in: International journal of environmental research and public health Vol. 17; no. 22; p. 8687
• Main Authors: Kim, Jinsun, Park, Eun Young, Park, Eunjung, Lim, Min Kyung, Oh, Jin-Kyoung, Kim, Byungmi
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI 23.11.2020
• Subjects: Aged; Cohort Studies; Colonic Neoplasms; Colorectal Neoplasms - epidemiology; Female; Humans; Male; Metabolic Syndrome - epidemiology; Middle Aged; Propensity Score; Risk Factors; metabolic syndrome; cohort; colorectal cancer; propensity score methods
• ISSN: 1660-4601; 1661-7827; 1660-4601
• DOI: 10.3390/ijerph17228687

Background: This study aimed to determine the effects of metabolic syndrome (MetS) on colorectal cancer (CRC) using propensity score (PS) methods. Methods: The study subjects were 2417 men and 4568 women from the Korean National Cancer Center (KNCC) Community Cohort enrolled between 2003 and 2010. Odds risks (ORs) and 95% confidence intervals (CIs) using PS matching analysis, regression models adjusted by the PS or stratified into five strata according to PS, and PS weighting methods were calculated. Results: In women, MetS and abnormally high triglyceride (TG) levels were associated with CRC risk using the PS matching analysis (ORs, for MetS, 2.19 (95% CI, 1.10–4.33); for abnormal TG levels, 2.08 (95% CI, 1.07–4.02)). However, there were no significant associations between MetS and TG levels and CRC risk in men. Conclusions: Our study might provide additional evidence that deteriorated metabolic profiles increase the risk of CRC in women rather than men. Thus, this may have an important role in effective population-level interventions for deteriorated metabolic profiles at an early stage.