Lycocasine A, a Lycopodium Alkaloid from Lycopodiastrum casuarinoides and Its Acid-Sensing Ion Channel 1a Inhibitory Activity

A novel Lycopodium alkaloid, lycocasine A (1), and seven known Lycopodium alkaloids (2–8), were isolated from Lycopodiastrum casuarinoides. Their structures were determined through NMR, HRESIMS, and X-ray diffraction analysis. Compound 1 features an unprecedented 5/6/6 tricyclic skeleton, highlighte...

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Published inMolecules (Basel, Switzerland) Vol. 29; no. 7; p. 1581
Main Authors Jiang, Shuai, Li, Wen-Yan, Gao, Bei-Bei, Zhao, Qin-Shi
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 01.04.2024
Subjects
Acid Sensing Ion Channels
acid-sensing ion channel 1a
Alkaloids - pharmacology
Azacitidine
Lycopodiaceae
Lycopodiastrum casuarinoides
Lycopodium
Lycopodium alkaloid
Proteins
Rheumatism
Rheumatoid arthritis
Lycopodiaceae
acid-sensing ion channel 1a
Lycopodiastrum casuarinoides
Lycopodium alkaloid
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ISSN1420-3049
1420-3049
DOI10.3390/molecules29071581

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Summary:A novel Lycopodium alkaloid, lycocasine A (1), and seven known Lycopodium alkaloids (2–8), were isolated from Lycopodiastrum casuarinoides. Their structures were determined through NMR, HRESIMS, and X-ray diffraction analysis. Compound 1 features an unprecedented 5/6/6 tricyclic skeleton, highlighted by a 5-aza-tricyclic[6,3,1,02,6]dodecane motif. In bioactivity assays, compound 1 demonstrated weak inhibitory activity against acid-sensing ion channel 1a.
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ISSN:1420-3049
1420-3049
DOI:10.3390/molecules29071581