Association between ALDH2 Polymorphism and Gastric Cancer Risk in a Korean Population

• Published in: Journal of Korean medical science Vol. 35; no. 17; pp. e148 - 6
• Main Authors: Choi, Chang Kyun, Kweon, Sun-Seog, Cho, Sang-Hee, Kim, Hye-Yeon, Shin, Min-Ho
• Format: Journal Article
• Language: English
• Published: Korea (South) The Korean Academy of Medical Sciences 04.05.2020; 대한의학회
• Subjects: Adult; Alcohol Drinking; Aldehyde Dehydrogenase, Mitochondrial - genetics; Alleles; Asian Continental Ancestry Group - genetics; Brief Communication; Case-Control Studies; Female; Genetic Predisposition to Disease; Genotype; Humans; Male; Middle Aged; Odds Ratio; Polymorphism, Single Nucleotide; Republic of Korea; Risk Factors; Sex Factors; Stomach Neoplasms - diagnosis; Stomach Neoplasms - genetics; 의학일반; Republic of Korea; ALDH2; Gastric Cancer; Alcohol Drinking
• ISSN: 1011-8934; 1598-6357; 1598-6357
• DOI: 10.3346/jkms.2020.35.e148

The association between alcohol and gastric cancer is stronger in East Asians than in other ethnic groups, presumably due to an aldehyde dehydrogenase 2 ( ) polymorphism. Therefore, we investigated the relationship between the rs671 polymorphism and gastric cancer in a Korean population. This case-control study included 3,245 hospital patients newly diagnosed with gastric cancer and 8,732 population controls. The rs671 genotype was classified as inactive (GG) or active (GA/AA). The risk of gastric cancer was higher in men with the inactive than in those with active (odds ratio [OR], 1.25; 95% confidence interval [CI], 1.09-1.39), whereas no significant association was found between genotype and gastric cancer in women (OR, 1.00; 95% CI, 0.99-1.02). In men, the association between genotype and gastric cancer was stronger in current drinkers. Our findings support the previously reported association between inactive and high risk of gastric cancer.