Risk Factors for Mortality in Patients with Serratia marcescens Bacteremia

• Published in: Yonsei medical journal Vol. 56; no. 2; pp. 348 - 354
• Main Authors: Kim, Sun Bean, Jeon, Yong Duk, Kim, Jung Ho, Kim, Jae Kyoung, Ann, Hea Won, Choi, Heun, Kim, Min Hyung, Song, Je Eun, Ahn, Jin Young, Jeong, Su Jin, Ku, Nam Su, Han, Sang Hoon, Choi, Jun Yong, Song, Young Goo, Kim, June Myung
• Format: Journal Article
• Language: English
• Published: Korea (South) Yonsei University College of Medicine 01.03.2015; 연세대학교의과대학
• Subjects: Adult; Aged; Aged, 80 and over; Anti-Bacterial Agents - therapeutic use; Bacteremia - drug therapy; Bacteremia - microbiology; Bacteremia - mortality; Cross Infection - mortality; Female; Humans; Intensive Care Units; Male; Middle Aged; Multiple Organ Failure; Original; Republic of Korea - epidemiology; Retrospective Studies; Risk Factors; Serratia Infections - diagnosis; Serratia Infections - drug therapy; Serratia Infections - mortality; Serratia marcescens - drug effects; Serratia marcescens - isolation & purification; Severity of Illness Index; Survival Rate; Time Factors; Treatment Outcome; 의학일반; Republic of Korea; mortality; risk factors; Serratia marcescens; bacteremia
• ISSN: 0513-5796; 1976-2437; 1976-2437
• DOI: 10.3349/ymj.2015.56.2.348

Over the last 30 years, Serratia marcescens (S. marcescens) has emerged as an important pathogen, and a common cause of nosocomial infections. The aim of this study was to identify risk factors associated with mortality in patients with S. marcescens bacteremia. We performed a retrospective cohort study of 98 patients who had one or more blood cultures positive for S. marcescens between January 2006 and December 2012 in a tertiary care hospital in Seoul, South Korea. Multiple risk factors were compared with association with 28-day all-cause mortality. The 28-day mortality was 22.4% (22/98 episodes). In a univariate analysis, the onset of bacteremia during the intensive care unit stay (p=0.020), serum albumin level (p=0.011), serum C-reactive protein level (p=0.041), presence of indwelling urinary catheter (p=0.023), and Sequential Oran Failure Assessment (SOFA) score at the onset of bacteremia (p<0.001) were significantly different between patients in the fatal and non-fatal groups. In a multivariate analysis, lower serum albumin level and an elevated SOFA score were independently associated with 28-day mortality [adjusted odds ratio (OR) 0.206, 95% confidential interval (CI) 0.044-0.960, p=0.040, and adjusted OR 1.474, 95% CI 1.200-1.810, p<0.001, respectively]. Lower serum albumin level and an elevated SOFA score were significantly associated with adverse outcomes in patients with S. marcescens bacteremia.