Effect of late-onset epilepsy on cognitive functioning in patients with small vessel disease

• Published in: Epilepsy & behavior Vol. 123; p. 108238
• Main Authors: Turon, Marc, Jiménez-Balado, Joan, Abraira, Laura, Fonseca, Elena, Quintana, Manuel, Toledo, Manuel, Delgado, Pilar, Maisterra, Olga, Salas-Puig, Xavier, Álvarez-Sabín, José, Santamarina, Estevo
• Format: Journal Article
• Language: English
• Published: Elsevier Inc 01.10.2021
• Subjects: Cognitive impairment; Dementia; Late-onset epilepsy; Memory; Small-vessel disease; Vascular burden; Vascular burden; Small-vessel disease; Late-onset epilepsy; Memory; Cognitive impairment; Dementia
• ISSN: 1525-5050; 1525-5069; 1525-5069
• DOI: 10.1016/j.yebeh.2021.108238

•Patients with cSVD-LOE showed poorer cognitive performance compared with patients with cSVD.•Cognitive profile in cSVD-LOE is different from that typically observed in cSVD.•Epilepsy was the major contributor to the decrease in verbal memory.•Seizure localization and vascular burden were not related with cognitive performance.•Epilepsy could be an early sign of incipient neurodegenerative disease in these patients. Late-onset epilepsy (LOE) often has underlying cerebrovascular cause and has been associated with neurocognitive deficits and dementia. Nevertheless, the interplay between these factors has not been studied thus far. Hence, we conducted a retrospective cross-sectional study aimed to explore how unprovoked epileptic seizures along with vascular-related factors contribute to neurocognitive impairments in patients with cerebral small vessel disease. Twenty-seven patients with LOE aged > 60 years with concomitant cerebral small vessel disease (cSVD) and a matched group of cSVD without epilepsy were cognitively assessed. Demographic, clinical, and vascular information were obtained and vascular burden score was calculated for each patient. Multiple linear regression models were used to explore the relationship between epilepsy and cognitive measures adjusting for demographic and vascular risk factors. Compared with cSVD, cSVD-LOE group showed a poorer performance on verbal memory measures, visuomotor tracking and speed processing and phonetic fluency. In the multiple regression analysis, the presence of epilepsy was found to be the major predictor for verbal memory dysfunction, specifically in verbal short recall (p = 0.008) and verbal learning (p < 0.001). No interactions between vascular burden and epilepsy were found. Patients who had cSVD with concurrent LOE showed poorer performance on memory function compared with patients with cSVD without epilepsy, and they showed a different cognitive profile from that typically manifested by patients with cSVD. The presence of epilepsy, but not seizure localization nor vascular burden, was the major contributor to the decrease in verbal memory.