Msx1 Gene Variant - its Association in Isolated Hypodontia: A Case Control Genetic study

• Published in: Indian journal of human genetics Vol. 19; no. 4; pp. 459 - 464
• Main Authors: Reddy, NaveenAdmala, Adusumilli, Gopinath, Devanna, Raghu, Mayur, RohraG, Pichai, Saravanan, Arujnan, Sharmila
• Format: Journal Article
• Language: English
• Published: India Medknow Publications and Media Pvt. Ltd 01.10.2013; Medknow Publications & Media Pvt. Ltd; Medknow Publications & Media Pvt Ltd
• Subjects: Case studies; Genetic aspects; Health aspects; Homeobox genes; Homeotic genes; Original; Tooth diseases; Varieties; India; tooth agenesis; MSX1 mutation; non-syndromic
• ISSN: 0971-6866; 1998-362X
• DOI: 10.4103/0971-6866.124376

Non-syndromic tooth agenesis is a congenital anomaly with significant medical, psychological, and social ramifications. There is sufficient evidence to hypothesize that locus for this condition can be identified by candidate genes. The aim of this study was to test whether MSX1 671 T > C gene variant was involved in etiology of non-syndromic tooth agenesis in Raichur patients. Blood samples were collected with informed consent from 50 subjects having non-syndromic tooth agenesis and 50 controls. Genomic deoxyribonucleic acid (DNA) was extracted from the blood samples, polymerase chain reaction (PCR) was performed, and restriction fragment length polymorphism (RFLP) was performed for digestion products that were evaluated. The results showed positive correlation between MSX1671 T > C gene variant and non-syndromic tooth agenesis in Raichur patients. MSX1 671 T > C gene variant may be a good screening marker for non-syndromic tooth agenesis in Raichur patients.