In‐hospital and home‐based long‐term monitoring of focal epilepsy with a wearable electroencephalographic device: Diagnostic yield and user experience

• Published in: Epilepsia (Copenhagen) Vol. 64; no. 4; pp. 937 - 950
• Main Authors: Macea, Jaiver, Bhagubai, Miguel, Broux, Victoria, De Vos, Maarten, Van Paesschen, Wim
• Format: Journal Article
• Language: English
• Published: United States Wiley Subscription Services, Inc 01.04.2023
• Subjects: Algorithms; Business metrics; Convulsions & seizures; EEG; Electroencephalography; Epilepsies, Partial - diagnosis; Epilepsy; focal seizure; Hospitals; Humans; machine learning; Patient satisfaction; Patients; real‐world data; seizure detection; Seizures; Seizures - diagnosis; Side effects; wearable devices; Wearable Electronic Devices; focal seizure; wearable devices; real-world data; seizure detection; machine learning
• ISSN: 0013-9580; 1528-1167; 1528-1157; 1528-1167
• DOI: 10.1111/epi.17517

Objective The aim is to report the performance of an electroencephalogram (EEG) seizure‐detector algorithm on data obtained with a wearable device (WD) in patients with focal refractory epilepsy and their experience. Methods Patients used a WD, the Sensor Dot (SD), to measure two channels of EEG using dry electrode patches during presurgical evaluation and at home for up to 8 months. An automated seizure detection algorithm flagged EEG regions with possible seizures, which we reviewed to evaluate the algorithm's diagnostic yield. In addition, we collected data on usability, side effects, and patient satisfaction with an electronic seizure diary application (Helpilepsy). Results Sixteen inpatients used the SD for up to 5 days and had 21 seizures. Sixteen outpatients used the device for up to 8 months and reported 101 focal impaired awareness seizures during the periods selected for analysis. Focal seizure detection sensitivity based on behind‐the‐ear EEG was 52% in inpatients and 23% in outpatients. False detections/h, positive predictive value (PPV), and F1 scores were 7.13%, .11%, and .002% for inpatients and 7.77%, .04%, and .001% for outpatients. Artifacts and low signal quality contributed to poor performance metrics. The seizure detector identified 19 nonreported seizures during sleep, when the signal quality was better. Regarding patients' experience, the likelihood of using the device at 6 months was 62%, and side effects were the main reason for dropping out. Finally, daily and monthly questionnaire completion rates were 33% and 65%, respectively. Significance Focal seizure detection sensitivity based on behind‐the‐ear EEG was 52% in inpatients and 23% in outpatients, with high false alarm rates and low PPV and F1 scores. This unobtrusive wearable seizure detection device was well received but had side effects. The current workflow and low performance limit its implementation in clinical practice. We suggest different steps to improve these performance metrics and patient experience.