Noninvasive evaluation of cerebrospinal fluid pressure in ocular hypertension: a preliminary study

• Published in: Acta ophthalmologica (Oxford, England) Vol. 96; no. 5; pp. e570 - e576
• Main Authors: Xie, Xiaobin, Chen, Weiwei, Li, Zhen, Thomas, Ravi, Li, Yong, Xian, Junfang, Yang, Diya, Wang, Huaizhou, Zhang, Shoukang, Kang, Zefeng, Wang, Ningli
• Format: Journal Article
• Language: English
• Published: England Wiley Subscription Services, Inc 01.08.2018
• Subjects: Blood pressure; Body mass index; cerebral spinal fluid pressure; Cerebrospinal fluid; Glaucoma; Magnetic resonance imaging; NMR; Noninvasive evaluation; Nuclear magnetic resonance; ocular hypertension; orbital subarachnoid space width; Subarachnoid space; trans‐lamina cribrosa pressure difference; trans-lamina cribrosa pressure difference; cerebral spinal fluid pressure; ocular hypertension; orbital subarachnoid space width
• ISSN: 1755-375X; 1755-3768; 1755-3768
• DOI: 10.1111/aos.13724

Purpose To compare the orbital cerebral spinal fluid pressure (CSFP) and trans‐lamina cribrosa pressure difference (TLCPD) determined noninvasively in ocular hypertensive (OH) subjects and controls. Methods Cross‐sectional observational study. Magnetic resonance imaging was used to measure orbital subarachnoid space width (OSASW). The CSFP (mm Hg) was estimated from a published formula as 17.54 × MRI derived OSASW at 15 mm behind the globe + 0.47 × body mass index + 0.13 × mean arterial blood pressure −21.52. Estimated TLCPD was calculated as IOP‐ CSFP. Results The orbital subarachnoid space width was significantly wider (p = 0.01) in the OH group than in the control group at all three measurement locations. The MRI derived CSFP value in OH (14.9 ± 2.9 mm Hg) was significantly higher than in the normal group (12.0 ± 2.8 mm Hg; p < 0.01). The estimated TLCPD value in OH (9.0 ± 4.2 mm Hg) was significantly higher than in controls (3.6 ± 3.0 mm Hg; p < 0.01). Conclusion The wider OSASW and higher estimated CSFP in OH subjects suggest a higher orbital CSFP. Despite a higher orbital CSFP that could be protective, the higher TLCPD in OH may play a significant role in the risk of developing glaucoma.