Optical coherence tomography of basal cell carcinoma: influence of location, subtype, observer variability and image quality on diagnostic performance

• Published in: British journal of dermatology (1951) Vol. 178; no. 5; pp. 1102 - 1110
• Main Authors: Holmes, J., Braunmühl, T., Berking, C., Sattler, E., Ulrich, M., Reinhold, U., Kurzen, H., Dirschka, T., Kellner, C., Schuh, S., Welzel, J.
• Format: Journal Article
• Language: English
• Published: England Oxford University Press 01.05.2018
• Subjects: Basal cell carcinoma; Carcinoma, Basal Cell - diagnostic imaging; Diagnosis; Humans; Medical diagnosis; Observer Variation; Prospective Studies; Quality; Sensitivity and Specificity; Skin cancer; Skin Neoplasms - diagnostic imaging; Tomography; Tomography, Optical Coherence
• ISSN: 0007-0963; 1365-2133; 1365-2133
• DOI: 10.1111/bjd.16154

Summary Background We previously described the principal results from an observational, prospective, multicentre, clinical trial of the diagnostic value of optical coherence tomography (OCT) for basal cell carcinoma (BCC) in a clinical setting. In this trial, much additional useful information was gathered that warranted further analysis, presented here. Objectives To investigate the influence of candidate diagnostic criteria, OCT image quality, lesion location, and observer confidence and interobserver variability on the diagnostic performance of OCT, and to assess its potential use for diagnosis of BCC subtypes. Methods A total of 234 clinically unclear ‘pink lesions’ were evaluated in three steps: after clinical examination, after adding dermoscopy and after adding OCT. In addition to the diagnoses (including lesion subtype), observers recorded which of 15 diagnostic criteria the OCT image contained, their confidence in the diagnoses, the OCT image quality and the anatomical location of the lesion. Results Diagnostic performance of OCT did not depend on the lesion's anatomical location. Good OCT image quality was correlated with improved diagnostic performance, but diagnostic performance for lesions with mediocre image quality was still better than by clinical and dermoscopic examination. The main reason for reduced image quality was superficial scales and crusting. Observer confidence in diagnosis was correlated with diagnostic performance. Interobserver diagnostic performance was consistently higher than clinical examination and dermoscopy across all sites. BCC subtype could be determined with moderate accuracy, but further independent image markers are required. Conclusion OCT is useful in the diagnosis of BCC. What's already known about this topic? Optical coherence tomography (OCT) is an emerging imaging modality that has been shown to have utility in the noninvasive diagnosis of basal cell carcinoma (BCC), and is more sensitive and more specific than clinical or dermoscopic examination alone. What does this study add? Lesion location does not affect diagnostic performance with OCT. Poor OCT image quality is associated with superficial scales and crusting, reducing diagnostic performance, but in these cases diagnosis with OCT is better than by clinical or dermoscopy examination alone. Observers’ diagnostic confidence increases when using OCT and their performance reflects this. Diagnostic performance is consistent between trained observers. BCC subtype can be diagnosed from OCT images with moderate accuracy. Linked Editorial: Rossi et al. Br J Dermatol 2018; 178:994–996. Plain language summary available online Respond to this article