Laryngeal motility alteration: A missing link between sleep apnea and vagus nerve stimulation for epilepsy

• Published in: Epilepsia (Copenhagen) Vol. 57; no. 1; pp. e24 - e27
• Main Authors: Zambrelli, Elena, Saibene, Alberto M., Furia, Francesca, Chiesa, Valentina, Vignoli, Aglaia, Pipolo, Carlotta, Felisati, Giovanni, Canevini, Maria Paola
• Format: Journal Article
• Language: English
• Published: United States Wiley Subscription Services, Inc 01.01.2016
• Subjects: Adult; Aged; Drug‐resistant epilepsy; Epilepsy; Epilepsy - therapy; Esophageal Motility Disorders - etiology; Female; Humans; Male; Middle Aged; Motility; Polysomnography; Sleep apnea; Sleep Apnea, Obstructive - etiology; Sleep breathing disorders; Sleep disorders; Statistics, Nonparametric; Vagus Nerve Stimulation - adverse effects; Vocal cord dysfunction; Vocal Cords - physiopathology; Vocal cord dysfunction; Sleep breathing disorders; Drug-resistant epilepsy
• ISSN: 0013-9580; 1528-1167
• DOI: 10.1111/epi.13252

Summary This study aimed to evaluate the prevalence and the relationship of sleep breathing disorders (SBDs) and laryngeal motility alterations in patients with drug‐resistant epilepsy after vagus nerve stimulator (VNS) implantation. Twenty‐three consecutive patients with medically refractory epilepsy underwent out‐of‐center sleep testing before and after VNS implantation. Eighteen eligible subjects underwent endoscopic laryngeal examination post‐VNS implantation. Statistical analysis was carried out to assess an association between laryngeal motility alterations and the onset/worsening of SBDs. After VNS implantation, 11 patients showed a new‐onset mild/moderate SBD. Half of the patients already affected by obstructive sleep apnea (OSA) showed worsening of SBD. All of the patients with a new‐onset OSA had a laryngeal pattern with left vocal cord adduction (LVCA) during VNS stimulation. The association between VNS‐induced LVCA and SBD was statistically significant. This study suggests an association between VNS and SBD, hinting to a pivotal role of laryngeal motility alterations. The relationship between SBD and VNS‐induced LVCA supports the need to routinely investigate sleep respiratory and laryngeal motility patterns before and after VNS implantation.