Assessment of the pectolinarin content and the radical scavenging-linked antiobesity activity of Cirsium setidens Nakai extracts

• Published in: Food science and biotechnology Vol. 24; no. 6; pp. 2235 - 2243
• Main Authors: Lee, Young-Jun, Lee, Jin-Ha, Kim, Young-Hyun, Kim, Jae-Hwan, Yu, Seok-Yeong, Kim, Dan-Bi, Lee, Jong Seok, Cho, Myoung Lae, Cho, Ju-Hyun, Kim, Bong Kyun, Lee, Boo-Yong, Lee, Ok-Hwan
• Format: Journal Article
• Language: English
• Published: Seoul The Korean Society of Food Science and Technology 01.12.2015; 한국식품과학회
• Subjects: adipogenesis; antioxidant activity; antioxidants; bioactive compounds; body weight; Chemistry; Chemistry and Materials Science; cholesterol; Cirsium; Food Science; gene expression regulation; glucose; high fat diet; ingredients; insulin; mice; Nutrition; transcription (genetics); transcription factors; triacylglycerols; 식품과학; Nakai; peroxisome proliferator-activated receptor; antiobesity; antioxidant activity; pectolinarin
• ISSN: 1226-7708; 2092-6456
• DOI: 10.1007/s10068-015-0298-2

Cirsium setidens Nakai contains bioactive compounds that exert biological activities. Method validation for analysis of the pectolinarin content in Cirsium setidens extracts (CSE) and radical scavenging-linked antiobesity activities using 3T3-L1 cells and C57BL/6 mice were performed. The pectolinarin content of CSE was 2.81±0.01 mg/g with a high degree of linearity in calibration curves ( R 2 =0.9999). CSE exhibited free radical-scavenging activities and a reducing power. CSE and pectolinarin inhibited lipid accumulation during adipogenesis of 3T3-L1 cells via down-regulation of adipogenic transcription factors. CSE supplementation suppressed body weight in C57BL/6 mice fed a high fat diet and reduced plasma total cholesterol, triglyceride, insulin, and glucose levels. Pectolinarin-enriched CSE can be considered as a good source of natural antioxidants and antiobesity ingredients.