Articulation rehabilitation induces cortical plasticity in adults with non-syndromic cleft lip and palate

• Published in: Aging (Albany, NY.) Vol. 12; no. 13; pp. 13147 - 13159
• Main Authors: Li, Zhen, Zhang, Wenjing, Li, Chunlin, Wang, Mengyue, Wang, Songjian, Chen, Renji, Zhang, Xu
• Format: Journal Article
• Language: English
• Published: United States Impact Journals 03.07.2020
• Subjects: Adult; Cerebral Cortex - diagnostic imaging; Cerebral Cortex - physiology; Cleft Lip - rehabilitation; Cleft Lip - surgery; Cleft Palate - rehabilitation; Cleft Palate - surgery; Female; Gray Matter - diagnostic imaging; Gray Matter - physiology; Humans; Magnetic Resonance Imaging; Male; Neuronal Plasticity - physiology; Research Paper; Speech Therapy; Young Adult; cortical complexity; gray matter volume (GMV); cortical thickness (CT); non-syndromic cleft lip and palate (NSCLP); articulation rehabilitation (AR)
• ISSN: 1945-4589; 1945-4589
• DOI: 10.18632/aging.103402

In this study, we investigated brain morphological changes in adults with non-syndromic cleft lip and palate (NSCLP) after articulation rehabilitation (AR). High-resolution T1 weighted brain magnetic resonance imaging data were analyzed from 45 adults with NSCLP after palatoplasty: 24 subjects were assessed before AR (bNSCLP) and 21 subjects were assessed after AR (aNSCLP). In addition, there were 24 age and sex matched controls. Intergroup differences of grey matter volume were evaluated as a comprehensive measure of the cortex; cortical thickness and cortical complexity (gyrification and fractal dimensions) were also analyzed. As compared to controls, the bNSCLP subjects exhibited altered indexes in frontal, temporal, and parietal lobes; these morphological changes are characteristic for adults with NSCLP. Importantly, as compared to the bNSCLP and control subjects, the aNSCLP subjects exhibited cortical plasticity in the regions involved in language, auditory, pronunciation planning, and execution functions. The AR-mediated cortical plasticity in aNSCLP subjects may be caused by AR-induced cortical neurogenesis, which might reflect the underlying neural mechanism during AR.